CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001379
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock 70 kDa protein 4 
Protein Synonyms/Alias
 Ischemia responsive 94 kDa protein 
Gene Name
 Hspa4 
Gene Synonyms/Alias
 Irp94 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
754SKLNLQNKQSLTADPubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
 MOD_RES 76 76 Phosphoserine (By similarity).
 MOD_RES 89 89 Phosphotyrosine (By similarity).
 MOD_RES 336 336 Phosphotyrosine (By similarity).
 MOD_RES 430 430 N6-acetyllysine (By similarity).
 MOD_RES 538 538 Phosphothreonine (By similarity).
 MOD_RES 546 546 Phosphoserine (By similarity).
 MOD_RES 660 660 Phosphotyrosine (By similarity).  
Keyword
 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Phosphoprotein; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 840 AA 
Protein Sequence
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSVGA AAKSQVISNA 60
KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG IKVTYMEEER NFTTEQVTAM 120
LLSKLKETAE SVLKKPVVDC VVSVPSFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA 180
YGIYKQDLPA LEEKPRNVVF VDMGHSAYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL 240
VNHFCEEFGK KYKLDIKSKV RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT 300
MNRGKFLEMC DDLLARVEPP LRSILDQSKL KKEDIYAVEI VGGATRIPAV KEKISKFFGK 360
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGSSDCEVF 420
PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV 480
KVRVNVHGIF SVSSAALVEV HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQPQTPA 540
ENKAESEEME TSQAGSKDKK MDQPPQAKKA KVKTSTVDLP IESQLLWQLD REMLGLYTEN 600
EGKMIMQDKL EKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNNFTL KLEDTENWLY 660
EDGEDQPKQV YVDKLAELRT LGQPIKTRFQ ESEERPKLFE ELGKQIQQYM KVISSFKNKE 720
DQYEHLDAAD MTKVEKSTNE AMEWMNSKLN LQNKQSLTAD PVVKTKEIEA KIKELTNICS 780
PIISKPKPKV EPPKEEPKHA EQNGPVDGQG DNPGTQAAEH GADTAVPSDG DKKLPEMDID 840 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005811; C:lipid particle; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0001822; P:kidney development; IEP:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
 GO:0043392; P:negative regulation of DNA binding; IMP:RGD.
 GO:0010629; P:negative regulation of gene expression; IMP:RGD.
 GO:0001933; P:negative regulation of protein phosphorylation; IMP:RGD.
 GO:0045766; P:positive regulation of angiogenesis; IEP:RGD.
 GO:0010628; P:positive regulation of gene expression; IMP:RGD.
 GO:0032092; P:positive regulation of protein binding; IDA:RGD.
 GO:0009408; P:response to heat; IDA:RGD. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.