UniProt Accession

 SEPT3_HUMAN; Q9UH03; B1AHR0; Q2NKJ7; Q59GF7; Q6IBZ6; Q8N3P3; Q9HD35 

Genbank Protein ID

 AF285107; AF285108; AF285109; CR456572; AL833942; Z99716; Z99716; CH471095; BC111779; AB209152 

Genbank Nucleotide ID

 AAG00517.1; AAG00518.1; AAG00519.1; CAG30458.1; CAD38797.1; CAI41693.1; CAQ07552.1; EAW60480.1; AAI11780.2; BAD92389.1 

Protein Name

 Neuronal-specific septin-3 

Protein Synonyms/Alias

  

Gene Name

 SEPT3 

Gene Synonyms/Alias

 SEP3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
226	EFKQRVRKELEVNGI	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). 

Sequence Annotation

 NP_BIND 68 75 GTP.
 NP_BIND 208 216 GTP.
 BINDING 102 102 GTP.
 BINDING 265 265 GTP; via amide nitrogen and carbonyl
 BINDING 280 280 GTP.
 MOD_RES 91 91 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0000910; P:cytokinesis; NAS:UniProtKB. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin.
 IPR008114; Septin3. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS

 PR01741; SEPTIN3.