UniProt Accession

 ATPO_RAT; Q06647 

Genbank Protein ID

 D13127; BC060544 

Genbank Nucleotide ID

 BAA02429.1; AAH60544.1 

Protein Name

 ATP synthase subunit O, mitochondrial 

Protein Synonyms/Alias

 Oligomycin sensitivity conferral protein; OSCP; Sperm flagella protein 4 

Gene Name

 Atp5o 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
53	YSAASKQKRLDQVEK	acetylation	[1]
60	KRLDQVEKELLRVGQ	acetylation	[1]
70	LRVGQLLKDPKVSLA	acetylation	[1]
73	GQLLKDPKVSLAVLN	acetylation	[1]
84	AVLNPYIKRSIKVKS	acetylation	[1]
93	SIKVKSLKDITTKEK	acetylation	[1]
98	SLKDITTKEKFSPLT	acetylation	[1]
100	KDITTKEKFSPLTAN	acetylation	[1]
176	QILNLEVKTDPSIMG	acetylation	[1]
192	MIVRIGEKYVDMSAK	acetylation	[1]
199	KYVDMSAKSKIQKLS	acetylation	[1]
207	SKIQKLSKAMRDLL*	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 

Sequence Annotation

 MOD_RES 60 60 N6-acetyllysine (By similarity).
 MOD_RES 70 70 N6-acetyllysine (By similarity).
 MOD_RES 158 158 N6-acetyllysine (By similarity).
 MOD_RES 176 176 N6-acetyllysine (By similarity).
 MOD_RES 192 192 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP synthesis; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
 GO:0005496; F:steroid binding; IDA:RGD.
 GO:0046034; P:ATP metabolic process; IDA:RGD.
 GO:0042776; P:mitochondrial ATP synthesis coupled proton transport; IEA:Compara. 

Interpro

 IPR000711; ATPase_F1-cplx_OSCP/dsu.
 IPR020781; ATPase_F1-cplx_OSCP/dsu_CS.
 IPR026015; ATPase_OSCP/delta_N. 

Pfam

 PF00213; OSCP 

SMART

  

PROSITE

 PS00389; ATPASE_DELTA 

PRINTS

 PR00125; ATPASEDELTA.