CPLM-014356

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-014356

UniProt Accession

FXR1_MOUSE; Q61584; Q8VCU4; Q9R1E2; Q9R1E3; Q9R1E4; Q9R1E5; Q9WUA7; Q9WUA8; Q9WUA9

Genbank Protein ID

X90875; AF124385; AF124394; AF124386; AF124387; AF124388; AF124389; AF124390; AF124391; AF124392; AF124393; AF124394; AF124386; AF124387; AF124388; AF124389; AF124390; AF124391; AF124392; AF124393; AF124394; AF124386; AF124387; AF124388; AF124389; AF124390; AF124391; AF124392; AF124393; AF124394; AF124386; AF124387; AF124388; AF124389; AF124390; AF124391; AF124392; AF124393; AF124394; AF124386; AF124387; AF124388; AF124389; AF124390; AF124391; AF124392; AF124393; AF124394; AF124386; AF124387; AF124388; AF124389; AF124390; AF124391; AF124392; AF124393; AF124394; AF124386; AF124387; AF124388; AF124389; AF124390; AF124391; AF124392; AF124393; BC019139

Genbank Nucleotide ID

CAA62383.1; AAD30211.1; AAD30212.1; AAD30212.1; AAD30212.1; AAD30212.1; AAD30212.1; AAD30212.1; AAD30212.1; AAD30212.1; AAD30212.1; AAD30213.1; AAD30213.1; AAD30213.1; AAD30213.1; AAD30213.1; AAD30213.1; AAD30213.1; AAD30213.1; AAD30213.1; AAD30214.1; AAD30214.1; AAD30214.1; AAD30214.1; AAD30214.1; AAD30214.1; AAD30214.1; AAD30214.1; AAD30214.1; AAD30215.1; AAD30215.1; AAD30215.1; AAD30215.1; AAD30215.1; AAD30215.1; AAD30215.1; AAD30215.1; AAD30215.1; AAD30216.1; AAD30216.1; AAD30216.1; AAD30216.1; AAD30216.1; AAD30216.1; AAD30216.1; AAD30216.1; AAD30216.1; AAD30217.1; AAD30217.1; AAD30217.1; AAD30217.1; AAD30217.1; AAD30217.1; AAD30217.1; AAD30217.1; AAD30217.1; AAD30218.1; AAD30218.1; AAD30218.1; AAD30218.1; AAD30218.1; AAD30218.1; AAD30218.1; AAD30218.1; AAD30218.1; AAH19139.1

Protein Name

Fragile X mental retardation syndrome-related protein 1

Protein Synonyms/Alias

mFxr1p

Gene Name

Fxr1

Gene Synonyms/Alias

Fxr1h

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
246	SNIQQARKVPGVTAI	ubiquitination	[1]
394	TRGPEREKGYATDES	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs.

Sequence Annotation

DOMAIN 4 50 Agenet-like 1.
DOMAIN 63 115 Agenet-like 2.
DOMAIN 222 251 KH 1.
DOMAIN 285 314 KH 2.
REGION 471 486 RNA-binding RGG-box.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 68 68 Phosphotyrosine.
MOD_RES 435 435 Phosphoserine.
MOD_RES 438 438 Phosphoserine (By similarity).
MOD_RES 449 449 Phosphoserine (By similarity).
MOD_RES 452 452 Phosphoserine (By similarity).
MOD_RES 474 474 Omega-N-methylated arginine (By
MOD_RES 514 514 Phosphoserine (By similarity).
MOD_RES 641 641 Phosphoserine.
MOD_RES 643 643 Phosphoserine (By similarity).
MOD_RES 667 667 Phosphothreonine (By similarity).

Keyword

Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Methylation; Myogenesis; Phosphoprotein; Reference proteome; Repeat; RNA-binding.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

677 AA

Protein Sequence

MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP PPPDIKKEIS 60
EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD ATYNEIVTFE RLRPVNQNKT 120
VKKNTFFKCT VDVPEDLREA CANENAHKDF KKAVGACRIF YHPETTQLMI LSASEATVKR 180
VNILSDMHLR SIRTKLMLMS RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN 240
IQQARKVPGV TAIELDEDTG TFRIYGESAE AVKKARGFLE FVEDFIQVPR NLVGKVIGKN 300
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL LEYHIAYLKE 360
VEQLRMERLQ IDEQLRQIGM GFRPSSTRGP EREKGYATDE STVSSVQGSR SYSGRGRGRR 420
GPNYTSGYGT NSELSNPSET ESERKDELSD WSLAGEDDRE TRHQRDSRRR PGGRGRSVSG 480
GRGRGGPRGG KSSISSVLKD PDSNPYSLLD NTESDQTADT DASESHHSTN RRRRSRRRRT 540
DEDAVLMDGL TESDTASVNE NGLDDSEKKP QRRNRSRRRR FRGQAEDRQP VTVADYISRA 600
ESQSRQRNLP RETLAKNKKE MAKDVIEEHG PSEKAINGPT SASGDEIPKL PRTLGEEKTK 660
TLKEDSTQEA AVLNGVS 677

Gene Ontology

GO:0043034; C:costamere; IDA:MGI.
GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IDA:MGI.
GO:0005844; C:polysome; IDA:MGI.
GO:0002151; F:G-quadruplex RNA binding; IDA:MGI.
GO:0003730; F:mRNA 3'-UTR binding; IDA:MGI.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
GO:0017148; P:negative regulation of translation; IDA:MGI.

Interpro

IPR008395; Agenet-like_dom.
IPR022034; Frag_X_MRP_fam.
IPR004087; KH_dom.
IPR004088; KH_dom_type_1.

Pfam

PF05641; Agenet
PF12235; FXR1P_C
PF00013; KH_1

SMART

SM00322; KH

PROSITE

PS51641; AGENET_LIKE
PS50084; KH_TYPE_1
PS50304; TUDOR

PRINTS