CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020876
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oligoribonuclease, mitochondrial 
Protein Synonyms/Alias
 RNA exonuclease 2 homolog; Small fragment nuclease 
Gene Name
 Rexo2 
Gene Synonyms/Alias
 Smfn 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
173IIDVSTVKELCRRWYacetylation[1, 2, 3, 4, 5, 6]
189EDYEFAPKKAASHRAubiquitination[7]
205DDISESIKELQFYRNubiquitination[7]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [7] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily
Sequence Annotation
 DOMAIN 43 207 Exonuclease.
 MOD_RES 122 122 Phosphotyrosine (By similarity).
 MOD_RES 184 184 Phosphotyrosine.  
Keyword
 Complete proteome; Exonuclease; Hydrolase; Manganese; Mitochondrion; Nuclease; Phosphoprotein; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 237 AA 
Protein Sequence
MLGVSLGARL LRGVGGRRGQ FGARGVSEGS AAMAAGESMA QRMVWVDLEM TGLDIEKDQI 60
IEMACLITDS DLNILAEGPN LIIKQPDELL DSMSDWCKEH HGKSGLTKAV KESTVTLQQA 120
EYEFLSFVRQ QTPPGLCPLA GNSVHADKKF LDKHMPQFMK HLHYRIIDVS TVKELCRRWY 180
PEDYEFAPKK AASHRALDDI SESIKELQFY RNNIFKKKTD EKKRKIIENG ETEKPVS 237 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0008408; F:3'-5' exonuclease activity; ISA:MGI.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR006055; Exonuclease.
 IPR013520; Exonuclease_RNaseT/DNA_pol3.
 IPR022894; Oligoribonuclease.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF00929; RNase_T 
SMART
 SM00479; EXOIII 
PROSITE
  
PRINTS