| Tag | Content |
|---|
| CPLM ID | CPLM-019055 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase MIB2 |
Protein Synonyms/Alias | Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1 |
Gene Name | MIB2 |
Gene Synonyms/Alias | SKD; ZZANK1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 224 | SQDGGEGKPGRVVDI | ubiquitination | [1] | | 388 | IGDLDTVKRLQAGHG | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity). |
Sequence Annotation | DOMAIN 59 138 MIB/HERC2 1.
DOMAIN 207 285 MIB/HERC2 2.
REPEAT 522 551 ANK 1.
REPEAT 555 584 ANK 2.
REPEAT 588 617 ANK 3.
REPEAT 621 653 ANK 4.
REPEAT 657 686 ANK 5.
REPEAT 691 721 ANK 6.
REPEAT 725 754 ANK 7.
REPEAT 758 786 ANK 8.
REPEAT 827 856 ANK 9.
ZN_FING 143 190 ZZ-type.
ZN_FING 890 925 RING-type 1.
ZN_FING 969 1002 RING-type 2.
MOD_RES 309 309 Phosphoserine (By similarity). |
Keyword | Actin-binding; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Endosome; Ligase; Metal-binding; Notch signaling pathway; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1013 AA |
Protein Sequence | MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA APPNMDPDPQ AGVQVGMRVV 60
RGVDWKWGQQ DGGEGGVGTV VELGRHGSPS TPDRTVVVQW DQGTRTNYRA GYQGAHDLLL 120
YDNAQIGVRH PNIICDCCKK HGLRGMRWKC RVCLDYDLCT QCYMHNKHEL AHAFDRYETA 180
HSRPVTLSPR QGLPRIPLRG IFQGAKVVRG PDWEWGSQDG GEGKPGRVVD IRGWDVETGR 240
SVASVTWADG TTNVYRVGHK GKVDLKCVGE AAGGFYYKDH LPRLGKPAEL QRRVSADSQP 300
FQHGDKVKCL LDTDVLREMQ EGHGGWNPRM AEFIGQTGTV HRITDRGDVR VQFNHETRWT 360
FHPGALTKHH SFWVGDVVRV IGDLDTVKRL QAGHGEWTDD MAPALGRVGK VVKVFGDGNL 420
RVAVAGQRWT FSPSCLVAYR PEEDANLDVA ERARENKSSL SVALDKLRAQ KSDPEHPGRL 480
VVEVALGNAA RALDLLRRRP EQVDTKNQGR TALQVAAYLG QVELIRLLLQ ARAGVDLPDD 540
EGNTALHYAA LGNQPEATRV LLSAGCRADA INSTQSTALH VAVQRGFLEV VRALCERGCD 600
VNLPDAHSDT PLHSAISAGT GASGIVEVLT EVPNIDVTAT NSQGFTLLHH ASLKGHALAV 660
RKILARARQL VDAKKEDGFT ALHLAALNNH REVAQILIRE GRCDVNVRNR KLQSPLHLAV 720
QQAHVGLVPL LVDAGCSVNA EDEEGDTALH VALQRHQLLP LVADGAGGDP GPLQLLSRLQ 780
ASGLPGSAEL TVGAAVACFL ALEGADVSYT NHRGRSPLDL AAEGRVLKAL QGCAQRFRER 840
QAGGGAAPGP RQTLGTPNTV TNLHVGAAPG PEAAECLVCS ELALLVLFSP CQHRTVCEEC 900
ARRMKKCIRC QVVVSKKLRP DGSEVASAAP APGPPRQLVE ELQSRYRQME ERITCPICID 960
SHIRLVFQCG HGACAPCGSA LSACPICRQP IRDRIQIFV 999 |
Gene Ontology | GO:0005768; C:endosome; IEA:UniProtKB-SubCell. GO:0004871; F:signal transducer activity; IMP:UniProtKB. GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |