UniProt Accession

 BPNT1_HUMAN; O95861; A8K7C8; D3DTA9; Q8WVL5; Q9UGJ3 

Genbank Protein ID

 AF125042; AJ249339; AK291943; CH471100; CH471100; BC017801 

Genbank Nucleotide ID

 AAD17329.1; CAB65115.1; BAF84632.1; EAW93306.1; EAW93308.1; AAH17801.1 

Protein Name

 3'(2'),5'-bisphosphate nucleotidase 1 

Protein Synonyms/Alias

 Bisphosphate 3'-nucleotidase 1; PAP-inositol 1,4-phosphatase; PIP 

Gene Name

 BPNT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	CATDLQTKADRLAQM	ubiquitination	[1]
189	LKEVPAGKHIITTTR	ubiquitination	[1]
245	FASPGCKKWDTCAPE	ubiquitination	[1]
274	GNVLQYHKDVKHMNS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. 

Sequence Annotation

 REGION 119 122 Substrate binding.
 REGION 195 198 Substrate binding.
 METAL 74 74 Magnesium 1.
 METAL 117 117 Magnesium 1.
 METAL 117 117 Magnesium 2.
 METAL 119 119 Magnesium 1; via carbonyl oxygen.
 METAL 120 120 Magnesium 2.
 METAL 247 247 Magnesium 2.
 BINDING 74 74 Substrate (By similarity).
 BINDING 247 247 Substrate.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Hydrolase; Lithium; Magnesium; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 308 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008441; F:3'(2'),5'-bisphosphate nucleotidase activity; TAS:ProtInc.
 GO:0004441; F:inositol-1,4-bisphosphate 1-phosphatase activity; IEA:Compara.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; TAS:Reactome.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR020583; Inositol_monoP_metal-BS.
 IPR000760; Inositol_monophosphatase.
 IPR020550; Inositol_monophosphatase_CS. 

Pfam

 PF00459; Inositol_P 

SMART

  

PROSITE

 PS00629; IMP_1
 PS00630; IMP_2 

PRINTS