UniProt Accession

 PPAL_YEAST; P40347; D6W477 

Genbank Protein ID

 U11057; L48604; Z49219; Z71255; U51033; AY692891; BK006949 

Genbank Nucleotide ID

 AAA99546.1; AAA80146.1; CAA89190.1; CAA94981.1; AAB68124.1; AAT92910.1; DAA11493.1 

Protein Name

 Low molecular weight phosphotyrosine protein phosphatase 

Protein Synonyms/Alias

 Low molecular weight cytosolic acid phosphatase; PTPase 

Gene Name

 LTP1 

Gene Synonyms/Alias

 YPR073C; YP9499.28C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
29	PMAEAIFKHEVEKAN	acetylation	[1]
34	IFKHEVEKANLENRF	acetylation	[1]
43	NLENRFNKIDSFGTS	acetylation	[1]
67	HRTVSICKQHGVKIN	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates (By similarity). 

Sequence Annotation

 ACT_SITE 14 14 Nucleophile (By similarity).
 ACT_SITE 20 20 By similarity.
 ACT_SITE 133 133 Proton donor (By similarity).
 MOD_RES 57 57 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0003993; F:acid phosphatase activity; IEA:EC.
 GO:0004725; F:protein tyrosine phosphatase activity; IDA:SGD. 

Interpro

 IPR023485; Ptyr_pPase_SF.
 IPR000106; Tyr_phospatase/Ars_reductase.
 IPR017867; Tyr_phospatase_low_mol_wt. 

Pfam

 PF01451; LMWPc 

SMART

 SM00226; LMWPc 

PROSITE

  

PRINTS

 PR00719; LMWPTPASE.