| Tag | Content |
|---|
| CPLM ID | CPLM-005259 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Enoyl-CoA delta isomerase 1, mitochondrial |
Protein Synonyms/Alias | 3,2-trans-enoyl-CoA isomerase; Delta(3),Delta(2)-enoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase |
Gene Name | Eci1 |
Gene Synonyms/Alias | Dci |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | NKRVLVEKEGEAGIA | acetylation | [1] | | 48 | EAGIAVMKFKNPPVN | acetylation | [1] | | 76 | LEKLENDKSIRGVIL | acetylation | [1] | | 206 | FPPAEALKVGLVDEV | acetylation | [1] | | 222 | PEDQVHSKARSVMAK | acetylation | [1] | | 229 | KARSVMAKWFTIPDH | acetylation | [1] | | 247 | LTKSMMRKATADNLI | acetylation | [1] | | 255 | ATADNLIKQREADIQ | acetylation | [1] | | 275 | ISRDSIQKSLHVYLE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. |
Sequence Annotation | REGION 93 97 Substrate binding (By similarity).
BINDING 140 140 Substrate; via amide nitrogen (By
BINDING 164 164 Substrate (By similarity).
MOD_RES 76 76 N6-acetyllysine (By similarity). |
Keyword | 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Fatty acid metabolism; Isomerase; Lipid metabolism; Mitochondrion; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 289 AA |
Protein Sequence | MALAAARRVL LQAGSRLGRR GAVDGARRFS NKRVLVEKEG EAGIAVMKFK NPPVNSLSLE 60
FLTEFVISLE KLENDKSIRG VILTSERPGI FSAGLDLMEM YGRNPAHYAE YWKAVQELWL 120
RLYLSNLTLI SAINGASPAG GCLMALTCDY RIMADNSKYT IGLNESLLGI VAPFWLKDNY 180
VNTIGHRAAE RALQLGTLFP PAEALKVGLV DEVVPEDQVH SKARSVMAKW FTIPDHSRQL 240
TKSMMRKATA DNLIKQREAD IQNFTSFISR DSIQKSLHVY LEKLKQKKG 289 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:RGD. GO:0004165; F:dodecenoyl-CoA delta-isomerase activity; IDA:RGD. GO:0042802; F:identical protein binding; IDA:RGD. GO:0006635; P:fatty acid beta-oxidation; TAS:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |