CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019747
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 1 
Protein Synonyms/Alias
 TPR repeat protein 1 
Gene Name
 TTC1 
Gene Synonyms/Alias
 TPR1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102EYLIELEKNMSDEEKubiquitination[1, 2]
109KNMSDEEKQKRREESacetylation[3, 4]
120REESTRLKEEGNEQFubiquitination[4]
128EEGNEQFKKGDYIEAacetylation[4]
128EEGNEQFKKGDYIEAubiquitination[1, 2]
129EGNEQFKKGDYIEAEubiquitination[4, 5]
152MCPSCFQKERSILFSubiquitination[4, 5]
180MAINDCSKAIQLNPSubiquitination[5]
234EACMRLPKQIEERNEubiquitination[5]
244EERNERLKEEMLGKLubiquitination[5]
250LKEEMLGKLKDLGNLubiquitination[5, 6]
272STENFQIKQDSSTGSubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
 REPEAT 116 149 TPR 1.
 REPEAT 155 188 TPR 2.
 REPEAT 189 222 TPR 3.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 90 90 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 292 AA 
Protein Sequence
MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE AHLQEDQGEE 60
ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL EKNMSDEEKQ KRREESTRLK 120
EEGNEQFKKG DYIEAESSYS RALEMCPSCF QKERSILFSN RAAARMKQDK KEMAINDCSK 180
AIQLNPSYIR AILRRAELYE KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN 240
ERLKEEMLGK LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR 292 
Gene Ontology
 GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
 GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
 GO:0006457; P:protein folding; NAS:UniProtKB. 
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS