CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004594
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Superoxide dismutase [Fe] 
Protein Synonyms/Alias
  
Gene Name
 sodB 
Gene Synonyms/Alias
 sod; sodA; Rv3846; MT3960; MTCY01A6.22c 
Created Date
 July 27, 2013 
Organism
 Mycobacterium tuberculosis 
NCBI Taxa ID
 1773 
Lysine Modification
Position
Peptide
Type
References
202AAATSQTKGLIFG**pupylation[1]
Reference
 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036
Functional Description
 Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. 
Sequence Annotation
 METAL 28 28 Iron.
 METAL 76 76 Iron.
 METAL 160 160 Iron.
 METAL 164 164 Iron.
 CROSSLNK 202 202 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 3D-structure; Complete proteome; Iron; Isopeptide bond; Metal-binding; Oxidoreductase; Reference proteome; Secreted; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 207 AA 
Protein Sequence
MAEYTLPDLD WDYGALEPHI SGQINELHHS KHHATYVKGA NDAVAKLEEA RAKEDHSAIL 60
LNEKNLAFNL AGHVNHTIWW KNLSPNGGDK PTGELAAAIA DAFGSFDKFR AQFHAAATTV 120
QGSGWAALGW DTLGNKLLIF QVYDHQTNFP LGIVPLLLLD MWEHAFYLQY KNVKVDFAKA 180
FWNVVNWADV QSRYAAATSQ TKGLIFG 207 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MTBBASE.
 GO:0005576; C:extracellular region; IDA:MTBBASE.
 GO:0042597; C:periplasmic space; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0005506; F:iron ion binding; IDA:MTBBASE.
 GO:0004784; F:superoxide dismutase activity; IDA:MTBBASE.
 GO:0052059; P:evasion or tolerance by symbiont of host-produced reactive oxygen species; TAS:Reactome.
 GO:0009405; P:pathogenesis; IMP:MTBBASE.
 GO:0051289; P:protein homotetramerization; IPI:MTBBASE.
 GO:0006979; P:response to oxidative stress; IMP:MTBBASE.
 GO:0006801; P:superoxide metabolic process; IEA:InterPro. 
Interpro
 IPR001189; Mn/Fe_SOD.
 IPR019833; Mn/Fe_SOD_BS.
 IPR019832; Mn/Fe_SOD_C.
 IPR019831; Mn/Fe_SOD_N. 
Pfam
 PF02777; Sod_Fe_C
 PF00081; Sod_Fe_N 
SMART
  
PROSITE
 PS00088; SOD_MN 
PRINTS
 PR01703; MNSODISMTASE.