UniProt Accession

 D3Z3P8_MOUSE; D3Z3P8 

Genbank Protein ID

 AC166056 

Genbank Nucleotide ID

  

Protein Name

 Estradiol 17 beta-dehydrogenase 5 

Protein Synonyms/Alias

  

Gene Name

 Akr1c6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	KIADGTVKREDIFYT	ubiquitination	[1]
70	IHFPMAMKPGENYLP	ubiquitination	[1]
78	PGENYLPKDENGKLI	acetylation	[2]
78	PGENYLPKDENGKLI	ubiquitination	[1]
102	WEAMEKCKDAGLAKS	ubiquitination	[1]
108	CKDAGLAKSIGVSNF	ubiquitination	[1]
122	FNRRQLEKILKKPGL	acetylation	[3]
125	RQLEKILKKPGLKYK	ubiquitination	[1]
132	KKPGLKYKPVCNQVE	acetylation	[2]
132	KKPGLKYKPVCNQVE	ubiquitination	[1]
148	HPYLNQGKLLDFCRS	ubiquitination	[1]
156	LLDFCRSKDIVLVAY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IDA:MGI.
 GO:0008202; P:steroid metabolic process; IDA:MGI. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00062; ALDOKETO_REDUCTASE_2 

PRINTS

 PR00069; ALDKETRDTASE.