CPLM-001109

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001109

UniProt Accession

ATP9A_HUMAN; O75110; E1P5Y3; E1P5Y4; Q5TFW5; Q5TFW6; Q5TFW9; Q6ZMF3; Q9NQK6; Q9NQK7

Genbank Protein ID

AL353799; AL138807; AL035684; AL353799; AL035684; AL138807; AL035684; AL138807; AL353799; AL035684; AL138807; AL353799; AL138807; AL035684; AL353799; AL138807; AL035684; AL353799; CH471077; CH471077; CH471077; CH471077; AB014511; AK172802

Genbank Nucleotide ID

CAI18889.1; CAI18889.1; CAI18889.1; CAI18890.1; CAI18890.1; CAI18890.1; CAI19202.1; CAI19202.1; CAI19202.1; CAI19203.1; CAI19203.1; CAI19203.1; CAI22924.1; CAI22924.1; CAI22924.1; CAI22925.1; CAI22925.1; CAI22925.1; EAW75597.1; EAW75598.1; EAW75599.1; EAW75600.1; BAA31586.1; BAD18775.1

Protein Name

Probable phospholipid-transporting ATPase IIA

Protein Synonyms/Alias

ATPase class II type 9A

Gene Name

ATP9A

Gene Synonyms/Alias

ATPIIA; KIAA0611

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
326	KGPTLTTKVRRTMSS	ubiquitination	[1]
790	MLYPELYKDLLKGRP	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Sequence Annotation

ACT_SITE 391 391 4-aspartylphosphate intermediate (By
METAL 785 785 Magnesium (By similarity).
METAL 789 789 Magnesium (By similarity).

Keyword

Alternative splicing; ATP-binding; Complete proteome; Endosome; Golgi apparatus; Hydrolase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1047 AA

Protein Sequence

MTDNIPLQPV RQKKRMDSRP RAGCCEWLRC CGGGEARPRT VWLGHPEKRD QRYPRNVINN 60
QKYNFFTFLP GVLFNQFKYF FNLYFLLLAC SQFVPEMRLG ALYTYWVPLG FVLAVTVIRE 120
AVEEIRCYVR DKEVNSQVYS RLTARGTVVG VVLYTGRELR SVMNTSNPRS KIGLFDLEVN 180
CLTKILFGAL VVVSLVMVAL QHFAGRWYLQ IIRFLLLFSN IIPISLRVNL DMGKIVYSWV 240
IRRDSKIPGT VVRSSTIPEQ LGRISYLLTD KTGTLTQNEM IFKRLHLGTV AYGLDSMDEV 300
QSHIFSIYTQ QSQDPPAQKG PTLTTKVRRT MSSRVHEAVK AIALCHNVTP VYESNGVTDQ 360
AEAEKQYEDS CRVYQASSPD EVALVQWTES VGLTLVGRDQ SSMQLRTPGD QILNFTILQI 420
FPFTYESKRM GIIVRDESTG EITFYMKGAD VVMAGIVQYN DWLEEECGNM AREGLRVLVV 480
AKKSLAEEQY QDFEARYVQA KLSVHDRSLK VATVIESLEM EMELLCLTGV EDQLQADVRP 540
TLETLRNAGI KVWMLTGDKL ETATCTAKNA HLVTRNQDIH VFRLVTNRGE AHLELNAFRR 600
KHDCALVISG DSLEVCLKYY EYEFMELACQ CPAVVCCRCA PTQKAQIVRL LQERTGKLTC 660
AVGDGGNDVS MIQESDCGVG VEGKEGKQAS LAADFSITQF KHLGRLLMVH GRNSYKRSAA 720
LSQFVIHRSL CISTMQAVFS SVFYFASVPL YQGFLIIGYS TIYTMFPVFS LVLDKDVKSE 780
VAMLYPELYK DLLKGRPLSY KTFLIWVLIS IYQGSTIMYG ALLLFESEFV HIVAISFTSL 840
ILTELLMVAL TIQTWHWLMT VAELLSLACY IASLVFLHEF IDVYFIATLS FLWKVSVITL 900
VSCLPLYVLK YLRRRFSPPS YSKLTS 926

Gene Ontology

GO:0005769; C:early endosome; IDA:UniProtKB.
GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0055037; C:recycling endosome; IDA:UniProtKB.
GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0019829; F:cation-transporting ATPase activity; IEA:InterPro.
GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO:0004012; F:phospholipid-translocating ATPase activity; IEA:EC.
GO:0045332; P:phospholipid translocation; NAS:UniProtKB.

Interpro

IPR023299; ATPase_P-typ_cyto_domN.
IPR018303; ATPase_P-typ_P_site.
IPR006539; ATPase_P-typ_Plipid-transp.
IPR008250; ATPase_P-typ_transduc_dom_A.
IPR001757; Cation_transp_P_typ_ATPase.
IPR023214; HAD-like_dom.

Pfam

PF00122; E1-E2_ATPase
PF00702; Hydrolase

SMART

PROSITE

PS00154; ATPASE_E1_E2

PRINTS

PR00119; CATATPASE.