UniProt Accession

 B4DEQ4_HUMAN; B4DEQ4 

Genbank Protein ID

 AC007136; AK293742 

Genbank Nucleotide ID

 BAG57165.1 

Protein Name

 MAP kinase-interacting serine/threonine-protein kinase 2 

Protein Synonyms/Alias

 cDNA FLJ53467, highly similar to MAP kinase-interactingserine/threonine-protein kinase 2 (EC 2.7.11.1) 

Gene Name

 MKNK2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	SILSHIHKRRHFNEL	ubiquitination	[1]
195	FESIQEGKYEFPDKD	ubiquitination	[2]
216	AAKDLISKLLVRDAK	ubiquitination	[1]
259	LQRNSCAKDLTSFAA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0007243; P:intracellular protein kinase cascade; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS