CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018126
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Liver carboxylesterase 1 
Protein Synonyms/Alias
 Acyl-coenzyme A:cholesterol acyltransferase; Carboxylesterase 1G; ES-x 
Gene Name
 Ces1 
Gene Synonyms/Alias
 Ces1g 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
301LEVSLKMKFGTVDFLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. 
Sequence Annotation
 ACT_SITE 221 221 Acyl-ester intermediate (By similarity).
 ACT_SITE 353 353 Charge relay system (By similarity).
 ACT_SITE 466 466 Charge relay system (By similarity).
 CARBOHYD 388 388 N-linked (GlcNAc...) (Potential).
 CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).
 DISULFID 87 116 By similarity.
 DISULFID 273 284 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Reference proteome; Serine esterase; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 565 AA 
Protein Sequence
MWLCALSLIS LTACLSLGHP SLPPVVHTVH GKVLGKYVTL EGFSQPVAVF LGVPFAKPPL 60
GSLRFAPPEP AEPWSFVKHT TSYPPLCYQN PEAALRLAEL FTNQRKIIPH KFSEDCLYLN 120
IYTPADLTQN SRLPVMVWIH GGGLVIDGAS TYDGVPLAVH ENVVVVVIQY RLGIWGFFST 180
EDEHSRGNWG HLDQVAALHW VQDNIANFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF 240
HRAIAQSSVI FNPCLFGRAA RPLAKKIAAL AGCKTTTSAA MVHCLRQKTE DELLEVSLKM 300
KFGTVDFLGD PRESYPFLPT VIDGVLLPKA PEEILAEKSF NTVPYMVGIN KHEFGWIIPM 360
FLDFPLSERK LDQKTAASIL WQAYPILNIS EKLIPAAIEK YLGGTEDPAT MTDLFLDLIG 420
DIMFGVPSVI VSRSHRDAGA PTYMYEYQYR PSFVSDDRPQ ELLGDHADEL FSVWGAPFLK 480
EGASEEEINL SKMVMKFWAN FARNGNPNGE GLPHWPEYDQ KEGYLQIGVP AQAAHRLKDK 540
EVDFWTELRA KETAERSSHR EHVEL 565 
Gene Ontology
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0004091; F:carboxylesterase activity; IBA:RefGenome.
 GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:EC.
 GO:0080032; F:methyl jasmonate esterase activity; IEA:EC.
 GO:0080031; F:methyl salicylate esterase activity; IEA:EC.
 GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC. 
Interpro
 IPR002018; CarbesteraseB.
 IPR019826; Carboxylesterase_B_AS.
 IPR019819; Carboxylesterase_B_CS. 
Pfam
 PF00135; COesterase 
SMART
  
PROSITE
 PS00122; CARBOXYLESTERASE_B_1
 PS00941; CARBOXYLESTERASE_B_2 
PRINTS