UniProt Accession

 PDLI1_HUMAN; O00151; B2RBS6; Q5VZH5; Q9BPZ9 

Genbank Protein ID

 U90878; AJ310549; AK314792; AY923052; AL160288; AL157834; AL157834; AL160288; BC000915; BC018755 

Genbank Nucleotide ID

 AAC05580.1; CAC32846.1; BAG37323.1; AAW82438.1; CAH70720.1; CAH70720.1; CAH72341.1; CAH72341.1; AAH00915.1; AAH18755.1 

Protein Name

 PDZ and LIM domain protein 1 

Protein Synonyms/Alias

 C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36 

Gene Name

 PDLIM1 

Gene Synonyms/Alias

 CLIM1; CLP36 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	GFRLVGGKDFEQPLA	ubiquitination	[1, 2]
309	EDQIYCEKHARERVT	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. 

Sequence Annotation

 DOMAIN 3 85 PDZ.
 DOMAIN 258 317 LIM zinc-binding.
 METAL 260 260 Zinc 1.
 METAL 263 263 Zinc 1.
 METAL 280 280 Zinc 1.
 METAL 283 283 Zinc 1.
 METAL 286 286 Zinc 2.
 METAL 289 289 Zinc 2.
 METAL 307 307 Zinc 2.
 METAL 310 310 Zinc 2.
 MOD_RES 2 2 N-acetylthreonine.
 MOD_RES 90 90 Phosphoserine.
 MOD_RES 130 130 Phosphoserine.
 MOD_RES 144 144 Phosphotyrosine.
 MOD_RES 321 321 Phosphotyrosine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; LIM domain; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0006979; P:response to oxidative stress; TAS:ProtInc. 

Interpro

 IPR001478; PDZ.
 IPR006643; ZASP.
 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM
 PF00595; PDZ 

SMART

 SM00132; LIM
 SM00228; PDZ
 SM00735; ZM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS50106; PDZ 

PRINTS