| Tag | Content |
|---|
| CPLM ID | CPLM-000253 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone demethylase UTY |
Protein Synonyms/Alias | Ubiquitously-transcribed TPR protein on the Y chromosome; Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein |
Gene Name | UTY |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 392 | STLAARIKFLQNGSD | ubiquitination | [1] | | 911 | HQFCTNPKNPVTVIR | ubiquitination | [1] | | 1041 | NIDLSDNKKWKLQLH | ubiquitination | [1] | | 1052 | LQLHELTKLPAFARV | ubiquitination | [1] | | 1207 | VERYEWNKLKSVKSP | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Histone demethylase (By similarity). |
Sequence Annotation | REPEAT 90 123 TPR 1.
REPEAT 127 160 TPR 2.
REPEAT 167 196 TPR 3.
REPEAT 202 235 TPR 4.
REPEAT 247 280 TPR 5.
REPEAT 281 314 TPR 6.
REPEAT 315 348 TPR 7.
REPEAT 349 382 TPR 8.
DOMAIN 1042 1205 JmjC.
METAL 1093 1093 Iron (By similarity).
METAL 1095 1095 Iron (By similarity). |
Keyword | 3D-structure; Alternative splicing; Chromatin regulator; Complete proteome; Dioxygenase; Direct protein sequencing; Iron; Metal-binding; Nucleus; Oxidoreductase; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1347 AA |
Protein Sequence | MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 60
EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 120
ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 180
KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 240
TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 300
FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 360
SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQNGSDN WNGGQSLSHH PVQQVYSLCL 420
TPQKLQHLEQ LRANRDNLNP AQKHQLEQLE SQFVLMQQMR HKEVAQVRTT GIHNGAITDS 480
SLPTNSVSNR QPHGALTRVS SVSQPGVRPA CVEKLLSSGA FSAGCIPCGT SKILGSTDTI 540
LLGSNCIAGS ESNGNVPYLQ QNTHTLPHNH TDLNSSTEEP WRKQLSNSAQ GLHKSQSSCL 600
SGPNEEQPLF STGSAQYHQA TSTGIKKANE HLTLPSNSVP QGDADSHLSC HTATSGGQQG 660
IMFTKESKPS KNRSLVPETS RHTGDTSNGC ADVKGLSNHV HQLIADAVSS PNHGDSPNLL 720
IADNPQLSAL LIGKANGNVG TGTCDKVNNI HPAVHTKTDH SVASSPSSAI STATPSPKST 780
EQRSINSVTS LNSPHSGLHT VNGEGLGKSQ SSTKVDLPLA SHRSTSQILP SMSVSICPSS 840
TEVLKACRNP GKNGLSNSCI LLDKCPPPRP PTSPYPPLPK DKLNPPTPSI YLENKRDAFF 900
PPLHQFCTNP KNPVTVIRGL AGALKLDLGL FSTKTLVEAN NEHMVEVRTQ LLQPADENWD 960
PTGTKKIWRC ESNRSHTTIA KYAQYQASSF QESLREENEK RTQHKDHSDN ESTSSENSGR 1020
RRKGPFKTIK FGTNIDLSDN KKWKLQLHEL TKLPAFARVV SAGNLLTHVG HTILGMNTVQ 1080
LYMKVPGSRT PGHQENNNFC SVNINIGPGD CEWFVVPEDY WGVLNDFCEK NNLNFLMSSW 1140
WPNLEDLYEA NVPVYRFIQR PGDLVWINAG TVHWVQAVGW CNNIAWNVGP LTACQYKLAV 1200
ERYEWNKLKS VKSPVPMVHL SWNMARNIKV SDPKLFEMIK YCLLKILKQY QTLREALVAA 1260
GKEVIWHGRT NDEPAHYCSI CEVEVFNLLF VTNESNTQKT YIVHCHDCAR KTSKSLENFV 1320
VLEQYKMEDL IQVYDQFTLA LSLSSSS 1347 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0051864; F:histone demethylase activity (H3-K36 specific); IEA:Compara. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. GO:0086003; P:cardiac muscle cell contraction; IEA:Compara. GO:0045184; P:establishment of protein localization; IEA:Compara. GO:0007507; P:heart development; IEA:Compara. GO:0001701; P:in utero embryonic development; IEA:Compara. GO:0031935; P:regulation of chromatin silencing; IEA:Compara. |
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SMART | |
PROSITE | |
PRINTS | |