CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013490
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 IST1 homolog 
Protein Synonyms/Alias
  
Gene Name
 Ist1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
48ADYLAAGKDERARIRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity). 
Sequence Annotation
  
Keyword
 Cell cycle; Cell division; Complete proteome; Cytoplasmic vesicle; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 366 AA 
Protein Sequence
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII 60
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV 120
ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD 180
SVVMAEAPVG VETDLIDVGF TDDVKKGGPG RGGGGGFTAP VGAPDGTMPM PMPMPMPMPS 240
PSPNAPFAYP LPKGPSDFSG LPVGTYQAFP NIHPPQIPAT PPSYESVDDI NADKNVSSAQ 300
IVGPKPEAPA KPPSRPVDNY NTFVLPELPS VPDTLPTASA GASTSASEDI DFDDLSRRFE 360
ELKKKT 366 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0048672; P:positive regulation of collateral sprouting; IEA:Compara. 
Interpro
 IPR005061; DUF292_euk. 
Pfam
 PF03398; Ist1 
SMART
  
PROSITE
  
PRINTS