CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034697
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Plasma membrane calcium-transporting ATPase 2 
Protein Synonyms/Alias
  
Gene Name
 Atp2b2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
12TNSDFYSKNQRNESSubiquitination[1]
45RGTEAVVKIKETYGDubiquitination[1]
61ESICRRLKTSPVEGLubiquitination[1]
77GTAPDLEKRKQIFGQacetylation[2]
77GTAPDLEKRKQIFGQubiquitination[1]
191SRIEQEQKFTVVRAGacetylation[2]
191SRIEQEQKFTVVRAGubiquitination[1]
254QVRKSVDKDPMLLSGacetylation[2]
254QVRKSVDKDPMLLSGubiquitination[1]
318DSSQSKAKQQDGAAAubiquitination[1]
332AMEMQPLKSAEGGDAubiquitination[1]
563RSQMPEEKLYKVYTFacetylation[2]
563RSQMPEEKLYKVYTFubiquitination[1]
601GASEIVLKKCCKILSacetylation[2]
769TDKHTLVKGIIDSTHacetylation[2]
1069EAGRLTQKEEIPEEEubiquitination[1]
1182SLYEGLEKPESRTSIubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1268 AA 
Protein Sequence
MGDMTNSDFY SKNQRNESSH GGEFGCSMEE LRSLMELRGT EAVVKIKETY GDTESICRRL 60
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG 120
LSFYHPPGES NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR 180
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS 240
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD 300
KKGKMQDGSA DSSQSKAKQQ DGAAAMEMQP LKSAEGGDAD DKKKANMHKK EKSVLQGKLT 360
KLAVQIGKAG LVMSAITVII LVLYFTVDTF VVNKKPWLTE CTPVYVQYFV KFFIIGVTVL 420
VVAVPEGLPL AVTISLAYSV KVREGKSRVR CLRQSQLFAH ASSVVQSKTS LIEESRRGRV 480
SFPTSTPHHR SIIVWAPVRT LKLHHLTHSL APTPAFRTKV LPPEKEGALP RQVGNKTECG 540
LLGFVLDLRQ DYEPVRSQMP EEKLYKVYTF NSVRKSMSTV IKMPDESFRM YSKGASEIVL 600
KKCCKILSGA GEPRVFRPRD RDEMVKKVIE PMACDGLRTI CVAYRDFPSS PEPDWDNEND 660
ILNELTCICV VGIEDPVRPE VPEAIRKCQR AGITVRMVTG DNINTARAIA IKCGIIHPGE 720
DFLCLEGKEF NRRIRNEKGE IEQERIDKIW PKLRVLARSS PTDKHTLVKG IIDSTHTEQR 780
QVVAVTGDGT NDGPALKKAD VGFAMGIAGT DVAKEASDII LTDDNFSSIV KAVMWGRNVY 840
DSISKFLQFQ LTVNVVAVIV AFTGACITQD SPLKAVQMLW VNLIMDTFAS LALATEPPTE 900
TLLLRKPYGR NKPLISRTMM KNILGHAVYQ LTLIFTLLFV GEKMFQIDSG RNAPLHSPPS 960
EHYTIIFNTF VMMQLFNEIN ARKIHGERNV FDGIFRNPIF CTIVLGTFAI QIVIVQFGGK 1020
PFSCSPLQLD QWMWCIFIGL GELVWGQVIA TIPTSRLKFL KEAGRLTQKE EIPEEELNED 1080
VEEIDHAERE LRRGQILWFR GLNRIQTQIE VVNTFKSGAS FQGALRRQSS VTSQSQDVAS 1140
LSSPSRVSLS NALSSPTSLP PAAAGIRVVK AFRSSLYEGL EKPESRTSIH NFMAHPEFRI 1200
EDSQPHIPLI DDTDLEEDAA LKQNSSPPSS LNKNNSAIDS GINLTTDTSK SATSSSPGSP 1260
IHSLETSL 1268 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005388; F:calcium-transporting ATPase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro. 
Interpro
 IPR022141; ATP_Ca_trans_C.
 IPR006408; ATPase_P-typ_Ca-transp_plasma.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF12424; ATP_Ca_trans_C
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
  
PRINTS
 PR00119; CATATPASE.