UniProt Accession

 SH21A_RAT; B2RZ59 

Genbank Protein ID

 BC167036; CH473991 

Genbank Nucleotide ID

 AAI67036.1; EDM10890.1 

Protein Name

 SH2 domain-containing protein 1A 

Protein Synonyms/Alias

  

Gene Name

 Sh2d1a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
89	NLISAFQKPDQGIVT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. 

Sequence Annotation

 DOMAIN 6 102 SH2.
 MOD_RES 89 89 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Reference proteome; SH2 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 126 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0007267; P:cell-cell signaling; IEA:Compara.
 GO:0006968; P:cellular defense response; IEA:InterPro.
 GO:0006959; P:humoral immune response; IEA:Compara.
 GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Compara. 

Interpro

 IPR000980; SH2.
 IPR017289; SH2_prot_1A. 

Pfam

 PF00017; SH2 

SMART

 SM00252; SH2 

PROSITE

 PS50001; SH2 

PRINTS

 PR00401; SH2DOMAIN.