CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021660
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Melanoma-associated antigen E1 
Protein Synonyms/Alias
 Alpha-dystrobrevin-associated MAGE Protein; DAMAGE; Hepatocellular carcinoma-associated protein 1; MAGE-E1 antigen 
Gene Name
 MAGEE1 
Gene Synonyms/Alias
 HCA1; KIAA1587 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
523EMREYIVKEYRNQFPubiquitination[1, 2]
734EVSSYSSKYAPHSWPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. 
Sequence Annotation
 DOMAIN 491 690 MAGE 1.
 DOMAIN 745 936 MAGE 2.
 REGION 743 957 Interaction with DTNA (By similarity).  
Keyword
 3D-structure; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleus; Polymorphism; Reference proteome; Repeat; Tumor antigen; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 957 AA 
Protein Sequence
MSLVSQNSRR RRRRVAKATA HNSSWGEMQA PNAPGLPADV PGSDVPQGPS DSQILQGLCA 60
SEGPSTSVLP TSAEGPSTFV PPTISEASSA SGQPTISEGP GTSVLPTPSE GLSTSGPPTI 120
SKGLCTSVTL AASEGRNTSR PPTSSEEPST SVPPTASEVP STSLPPTPGE GTSTSVPPTA 180
YEGPSTSVVP TPDEGPSTSV LPTPGEGPGT SVPLAATEGL STSVQATPDE GPSTSVPPTA 240
TEGLSTPVPP TRDEGPSTSV PATPGEGPST SVLPAASDGQ SISLVPTRGK GSSTSVPPTA 300
TEGLSTSVQP TAGEGSSTSV PPTPGGGLST SVPPTATEEL STSVPPTPGE GPSTSVLPIP 360
GEGLSTSVPP TASDGSDTSV PPTPGEGAST LVQPTAPDGP GSSVLPNPGE GPSTLFSSSA 420
SVDRNPSKCS LVLPSPRVTK ASVDSDSEGP KGAEGPIEFE VLRDCESPNS ISIMGLNTSR 480
VAITLKPQDP MEQNVAELLQ FLLVKDQSKY PIRESEMREY IVKEYRNQFP EILRRAAAHL 540
ECIFRFELRE LDPEAHTYIL LNKLGPVPFE GLEESPNGPK MGLLMMILGQ IFLNGNQAKE 600
AEIWEMLWRM GVQRERRLSI FGNPKRLLSV EFVWQRYLDY RPVTDCKPVE YEFFWGPRSH 660
LETTKMKILK FMAKIYNKDP MDWPEKYNEA LEEDAARAFA EGWQALPHFR RPFFEEAAAE 720
VPSPDSEVSS YSSKYAPHSW PESRLESKAR KLVQLFLLMD STKLPIPKKG ILYYIGRECS 780
KVFPDLLNRA ARTLNHVYGT ELVVLDPRNH SYTLYNRREM EETEEIVDSP NRPGNNFLMQ 840
VLSFIFIMGN HARESAVWAF LRGLGVQAGR KHVITCRYLS QRYIDSLRVP DSDPVQYEFV 900
WGPRARLETS KMKALRYVAR IHRKEPQDWP QQYREAMEDE ANRADVGHRQ IFVHNFR 957 
Gene Ontology
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0016010; C:dystrophin-associated glycoprotein complex; IEA:Compara.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; ISS:UniProtKB. 
Interpro
 IPR002190; MAGE. 
Pfam
 PF01454; MAGE 
SMART
  
PROSITE
 PS50838; MAGE 
PRINTS