CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024092
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Flotillin-1 
Protein Synonyms/Alias
 Reggie-2; REG-2 
Gene Name
 Flot1 
Gene Synonyms/Alias
 Reg2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
166DYLHSLGKARTAQVQacetylation[1]
277QEIARREKELEARVRacetylation[1]
423ISQVNHNKPLRTA**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. 
Sequence Annotation
 MOD_RES 19 19 Phosphoserine (By similarity).
 MOD_RES 385 385 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Endosome; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 428 AA 
Protein Sequence
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG 60
VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI 120
YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE 180
AEAKRDAGIR EAKAKQEKVS AQCLSEIEMA KAQRDYELKK ATYDIEVNTR RAQADLAYQL 240
QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYRLERLAEA 300
EKAQLIMQAE AEAESVRMRG EAEAFAVGAR ARAEAEQMAK KAEAFQMYQE AAQLDMLLEK 360
LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI LSRLPESVER LTGVSISQVN 420
HNKPLRTA 428 
Gene Ontology
 GO:0034451; C:centriolar satellite; IEA:Compara.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0016600; C:flotillin complex; IDA:RGD.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:0007409; P:axonogenesis; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; IEA:Compara.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:Compara. 
Interpro
 IPR001107; Band_7. 
Pfam
 PF01145; Band_7 
SMART
 SM00244; PHB 
PROSITE
  
PRINTS