UniProt Accession

 NCAM1_HUMAN; P13591; A8K8T8; P13592; P13593; Q05C58; Q15829; Q16180; Q16209; Q59FL7; Q86X47; Q96CJ3 

Genbank Protein ID

 X16841; U63041; S71824; AK292453; AB209443; BC014205; BC029119; BC047244; S73101; M17410; M17409; M22094; M22092; M22091 

Genbank Nucleotide ID

 CAA34739.1; AAB04558.1; AAB31836.1; BAF85142.1; BAD92680.1; AAH14205.2; AAH29119.1; AAH47244.1; AAB20698.1; AAA59913.1; AAA59912.1; AAA59910.1; AAA59911.1; AAA59911.1 

Protein Name

 Neural cell adhesion molecule 1 

Protein Synonyms/Alias

 N-CAM-1; NCAM-1; CD56 

Gene Name

 NCAM1 

Gene Synonyms/Alias

 NCAM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
771	EGKAAFSKDESKEPI	ubiquitination	[1]
775	AFSKDESKEPIVEVR	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 

Sequence Annotation

 DOMAIN 20 111 Ig-like C2-type 1.
 DOMAIN 116 205 Ig-like C2-type 2.
 DOMAIN 212 301 Ig-like C2-type 3.
 DOMAIN 308 413 Ig-like C2-type 4.
 DOMAIN 416 501 Ig-like C2-type 5.
 DOMAIN 506 605 Fibronectin type-III 1.
 DOMAIN 608 702 Fibronectin type-III 2.
 MOD_RES 784 784 Phosphoserine (By similarity).
 CARBOHYD 222 222 N-linked (GlcNAc...) (Potential).
 CARBOHYD 315 315 N-linked (GlcNAc...) (Potential).
 CARBOHYD 347 347 N-linked (GlcNAc...) (Potential).
 CARBOHYD 433 433 N-linked (GlcNAc...) (Potential).
 CARBOHYD 459 459 N-linked (GlcNAc...).
 CARBOHYD 488 488 N-linked (GlcNAc...) (Potential).
 DISULFID 41 96 Probable.
 DISULFID 139 189 Probable.
 DISULFID 235 287 Probable.
 DISULFID 329 395 Probable.
 DISULFID 436 489 Probable.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 858 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0030424; C:axon; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0034109; P:homotypic cell-cell adhesion; IEA:Compara.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Compara.
 GO:0001928; P:regulation of exocyst assembly; IEA:Compara. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR009138; Neural_cell_adh. 

Pfam

 PF00041; fn3
 PF07679; I-set 

SMART

 SM00060; FN3
 SM00408; IGc2 

PROSITE

 PS50853; FN3
 PS50835; IG_LIKE 

PRINTS

 PR01838; NCAMFAMILY.