Tag | Content |
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CPLM ID | CPLM-008751 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Squalene synthase |
Protein Synonyms/Alias | SQS; SS; FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase |
Gene Name | Fdft1 |
Gene Synonyms/Alias | Erg9 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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30 | GRRNFIPKMDQDSLS | ubiquitination | [1] | 41 | DSLSSSLKTCYKYLN | ubiquitination | [1] | 138 | EFRNLAEKYQTVIDD | ubiquitination | [1] | 229 | EDQQEGRKFWPQEVW | ubiquitination | [1] | 318 | KGVVKIRKGQAVTLM | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway. |
Sequence Annotation | |
Keyword | Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Endoplasmic reticulum; Isoprene biosynthesis; Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane; Multifunctional enzyme; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 416 AA |
Protein Sequence | MEFVKCLGHP EEFYNLLRFR MGGRRNFIPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA 60 LDGDIRHAIC VFYLVLRALD TVEDDMSISV EKKIPLLCNF HTFLYDPEWR FTESKEKDRQ 120 VLEDFPTISL EFRNLAEKYQ TVIDDICHRM GCGMAEFVDK DVTSKQDWDK YCHYVAGLVG 180 IGLSRLFSAS EFEDPIVGED IECANSMGLF LQKTNIIRDY LEDQQEGRKF WPQEVWGRYI 240 KKLEDFAKPE NVDVAVQCLN ELITNTLQHI PDVLTYLSRL RNQSVFNFCA IPQVMAIATL 300 AACYNNQQVF KGVVKIRKGQ AVTLMMDATN MPAVKAIIYQ YIEEIYHRIP NSDPSSSKTK 360 QVISKIRTQN LPNCQLISRS HYSPIYLSFI MLLAALSWQY LSTLSQVTED YVQREH 416 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004310; F:farnesyl-diphosphate farnesyltransferase activity; IEA:EC. GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. GO:0051996; F:squalene synthase activity; IEA:EC. GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW. GO:0045338; P:farnesyl diphosphate metabolic process; IEA:Compara. GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. |
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PROSITE | |
PRINTS | |