CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023900
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protocadherin alpha-C2 
Protein Synonyms/Alias
 PCDH-alpha-C2 
Gene Name
 PCDHAC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
647GEIRTTRKMGDESGSubiquitination[1]
758RSPAELYKQANNNIDubiquitination[1, 2]
773ARIPHGLKVQPHFIEubiquitination[1]
847AGNLIILKNEAVSQNubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 
Sequence Annotation
 DOMAIN 43 148 Cadherin 1.
 DOMAIN 149 257 Cadherin 2.
 DOMAIN 258 365 Cadherin 3.
 DOMAIN 374 469 Cadherin 4.
 DOMAIN 470 579 Cadherin 5.
 DOMAIN 594 691 Cadherin 6.
 REPEAT 856 859 PXXP 1.
 REPEAT 889 892 PXXP 2.
 REPEAT 930 933 PXXP 3.
 REPEAT 948 951 PXXP 4.
 REGION 856 951 4 X 4 AA repeats of P-X-X-P.
 CARBOHYD 280 280 N-linked (GlcNAc...) (Potential).
 CARBOHYD 436 436 N-linked (GlcNAc...) (Potential).
 CARBOHYD 586 586 N-linked (GlcNAc...) (Potential).
 CARBOHYD 657 657 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1007 AA 
Protein Sequence
MEQAGTRPAA TEHPRLRRPM PWLLLLPLLL LLLLLLPGPA ASQLRYSVPE EQAPGALVGN 60
VARALGLELR RLGPGCLRIN HLGAPSPRYL ELDLTSGALF VNERIDREAL CEQRPRCLLS 120
LEVLAHNPVA VSAVEVEILD INDNSPRFPR PNYQLQVSES VAPGARFHIE SAQDPDVGAN 180
SVQTYELSPS EHFELDLKPL QENSKVLELV LRKGLDREQA ALHHLVLTAV DGGIPARSGT 240
AQISVRVLDT NDNSPAFDQS TYRVQLREDS PPGTLVVKLN ASDPDEGSNG ELRYSLSSYT 300
SDRERQLFSI DASTGEVRVI GGLDYEEASS YQIYVQATDR GPVPMAGHCK VLVDIVDVND 360
NAPEVVLTDL YSPVPENATP NTIVAVLSVN DQDSGPNRKV SLGLEATLPF RLNGFGNSYT 420
LVVSGPLDRE RVAVYNITVT ATDGGIPQLT SLRTLKVEIS DINDNPPSFL EDSYSIYIQE 480
NNLPGVLLCT VQATDPDEKE NAEVTYSLLE REIQGLPVTS YVSINSASGS LYAVNSFDYE 540
KFREFFVTVE AQDKGSPPLS STVTANVYVV DMNDHAPHIL YPTSTNSSAA FEMVPRTAPA 600
GYLVTKVIAM DSDSGQNAWL FYHLAQTSDL DLFKVELHTG EIRTTRKMGD ESGSTFNLTV 660
VVRDNGEPSL SASVAITVAV VDRVSKILPD TQRHVKSPRT YSEITLYLII ALSTVSFIFL 720
LTIIILSIIK CYRYTAYGTA CCGGFCGVRE RSPAELYKQA NNNIDARIPH GLKVQPHFIE 780
VRGNGSLTKT YCYKACLTAG SGSDTFMFYN TGAQTGPGPS GAQAAVTDSR NLTGQSGQNA 840
GNLIILKNEA VSQNEPRQPN PDWRYSASLR AGMHSSVHLE EAGILRAGPG GPDQQWPTVS 900
SATPEPEAGE VSPPVGAGVN SNSWTFKYGP GNPKQSGPGE LPDKFIIPGS PAIISIRQEP 960
TNSQIDKSDF ITFGKKEETK KKKKKKKGNK TQEKKEKGNS TTDNSDQ 1007 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro.
 GO:0007399; P:nervous system development; TAS:ProtInc. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR013164; Cadherin_N. 
Pfam
 PF00028; Cadherin
 PF08266; Cadherin_2 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.