CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal peptidase I 
Protein Synonyms/Alias
 SPase I; Leader peptidase I 
Gene Name
 lepB 
Gene Synonyms/Alias
 STM2582 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
53LDNATLNKVAPKPGWacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 ACT_SITE 91 91 By similarity.
 ACT_SITE 146 146 By similarity.  
Keyword
 Cell inner membrane; Cell membrane; Complete proteome; Hydrolase; Membrane; Protease; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 324 AA 
Protein Sequence
MANMFALILV IATLVTGILW CVDKFVFAPK RRARQAAAQT ASGDALDNAT LNKVAPKPGW 60
LETGASVFPV LAIVLIVRSF LYEPFQIPSG SMMPTLLIGD FILVEKFAYG IKDPIYQKTL 120
IETGHPKRGD IVVFKYPEDP KLDYIKRAVG LPGDKITYDP VAKEVTIQPG CSSGQACENA 180
LPVTYSNVEP SDFVQTFARR NGGEATSGFF EVPLNETKEN GIRLTERKET LGDVTHRILM 240
VPIAQDQLGM YYQQPGQPLA TWVVPPGQYF MMGDNRDNSA DSRYWGFVPE ANLVGKAVAI 300
WMSFDKQEGE WPTGVRLSRI GGIH 324 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR000223; Pept_S26A_signal_pept_1.
 IPR019758; Pept_S26A_signal_pept_1_CS.
 IPR019757; Pept_S26A_signal_pept_1_Lys-AS.
 IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
 IPR019759; Peptidase_S24_S26.
 IPR015927; Peptidase_S24_S26A/B/C.
 IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
 IPR019533; Peptidase_S26.
 IPR019766; Peptidase_S26A_all-beta_subdom. 
Pfam
 PF00717; Peptidase_S24
 PF10502; Peptidase_S26 
SMART
  
PROSITE
 PS00501; SPASE_I_1
 PS00760; SPASE_I_2
 PS00761; SPASE_I_3 
PRINTS
 PR00727; LEADERPTASE.