UniProt Accession

 E7EW20_HUMAN; E7EW20 

Genbank Protein ID

 AL109897; AL136093; AL392166 

Genbank Nucleotide ID

  

Protein Name

 Unconventional myosin-VI 

Protein Synonyms/Alias

  

Gene Name

 MYO6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
196	LEAFGNAKTVRNNNS	ubiquitination	[1, 2]
334	IGLDDEEKLDLFRVV	acetylation	[3]
425	NARDALAKTVYSHLF	ubiquitination	[4, 5]
637	DTKQKAGKLSFISVG	ubiquitination	[2]
646	SFISVGNKFKTQLNL	ubiquitination	[1, 2, 4, 5, 6]
648	ISVGNKFKTQLNLLL	ubiquitination	[1, 2]
736	LDPRLFCKALFKALG	ubiquitination	[6]
750	GLNENDYKFGLTKVF	ubiquitination	[4, 5]
755	DYKFGLTKVFFRPGK	ubiquitination	[4, 5, 6]
782	DHLAELVKRVNHWLT	ubiquitination	[1]
886	DTLMAKIKSTMMTQE	ubiquitination	[1]
897	MTQEQIQKEYDALVK	ubiquitination	[1, 2]
993	EAQLARQKEEESQQQ	ubiquitination	[1, 2, 7, 8]
1077	GPAVLATKAAAGTKK	ubiquitination	[1, 2, 4, 5, 7, 8, 9]
1091	KYDLSKWKYAELRDT	ubiquitination	[4, 5]
1120	EEFHRRLKVYHAWKS	ubiquitination	[2, 4, 5, 6]
1142	ETEQRAPKSVTDYAQ	ubiquitination	[1, 2, 4, 5, 6, 7, 8]
1184	IRPADQYKDPQSKKK	ubiquitination	[1, 2, 4, 5, 6]
1189	QYKDPQSKKKGWWYA	ubiquitination	[2]
1286	AMLQSLLK*******	ubiquitination	[6]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [8] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [9] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1286 AA 

Protein Sequence

Gene Ontology

 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 

Interpro

 IPR000048; IQ_motif_EF-hand-BS.
 IPR001609; Myosin_head_motor_dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00063; Myosin_head 

SMART

 SM00015; IQ
 SM00242; MYSc 

PROSITE

  

PRINTS

 PR00193; MYOSINHEAVY.