| Tag | Content |
|---|
| CPLM ID | CPLM-017417 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MARVEL domain-containing protein 2 |
Protein Synonyms/Alias | Tricellulin |
Gene Name | MARVELD2 |
Gene Synonyms/Alias | TRIC |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 175 | TVRTYSEKVEEYNLR | ubiquitination | [1] | | 391 | NEPSLSSKRKMCEMA | ubiquitination | [1] | | 412 | RDSEVNFKELRTAKM | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing. |
Sequence Annotation | DOMAIN 188 367 MARVEL.
MOD_RES 116 116 Phosphoserine.
MOD_RES 120 120 Phosphoserine. |
Keyword | Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Deafness; Hearing; Membrane; Non-syndromic deafness; Phosphoprotein; Polymorphism; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 558 AA |
Protein Sequence | MSNDGRSRNR DRRYDEVPSD LPYQDTTIRT HPTLHDSERA VSADPLPPPP LPLQPPFGPD 60
FYSSDTEEPA IAPDLKPVRR FVPDSWKNFF RGKKKDPEWD KPVSDIRYIS DGVECSPPAS 120
PARPNHRSPL NSCKDPYGGS EGTFSSRKEA DAVFPRDPYG SLDRHTQTVR TYSEKVEEYN 180
LRYSYMKSWA GLLRILGVVE LLLGAGVFAC VTAYIHKDSE WYNLFGYSQP YGMGGVGGLG 240
SMYGGYYYTG PKTPFVLVVA GLAWITTIII LVLGMSMYYR TILLDSNWWP LTEFGINVAL 300
FILYMAAAIV YVNDTNRGGL CYYPLFNTPV NAVFCRVEGG QIAAMIFLFV TMIVYLISAL 360
VCLKLWRHEA ARRHREYMEQ QEINEPSLSS KRKMCEMATS GDRQRDSEVN FKELRTAKMK 420
PELLSGHIPP RPANFFVFLV EMGFHRVSQD DLDLLTS 457 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0033010; C:paranodal junction; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara. GO:0005923; C:tight junction; IDA:MGI. GO:0045216; P:cell-cell junction organization; IMP:MGI. GO:0007605; P:sensory perception of sound; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |