CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018506
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongator complex protein 2 
Protein Synonyms/Alias
 ELP2; STAT3-interacting protein 1; StIP1 
Gene Name
 Elp2 
Gene Synonyms/Alias
 Statip1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
99LENNQVLKSVRLQGHubiquitination[1]
248KPASFETKDGSLRLKubiquitination[1]
461FVSGADEKVLRVFSAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Regulates the ligand-dependent activation of STAT3. 
Sequence Annotation
 REPEAT 56 100 WD 1.
 REPEAT 105 152 WD 2.
 REPEAT 158 200 WD 3.
 REPEAT 205 246 WD 4.
 REPEAT 280 328 WD 5.
 REPEAT 338 377 WD 6.
 REPEAT 385 424 WD 7.
 REPEAT 438 476 WD 8.
 REPEAT 565 609 WD 9.
 REPEAT 612 651 WD 10.
 REPEAT 667 706 WD 11.
 REPEAT 718 762 WD 12.
 REPEAT 775 831 WD 13.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 831 AA 
Protein Sequence
MVSSVLEVSH VFCCPNRVRG ALSWNTGPGG LLAFGTSCSV VLYDPQKKVV ITNLNGHTAR 60
VNCLQWIRTE DGSPSNELVS GGSDNRVIHW ELENNQVLKS VRLQGHEGPV CAVHAIYQSG 120
PSEGEQHALI ASAASDSTVR IWSKKGSEVK YLQTLSFRDG FVLSVCLAIL PGTNVPVLAC 180
GDDDCRIHLY IQQDDQFQKA LSLCGHEDWI RGVEWATFGR DLFLASCSQD CLIRIWRLYM 240
KPASFETKDG SLRLKENTFT IKDGGVRTTV AVTLETVLAG HENWVNAVHW QPSFYKDGVL 300
QQPVRLLSAS MDKTMILWAP DEESGVWLEQ VRVGEVGGNT LGFYDCQFGE NGTMIIAHAF 360
HGALHLWKQS TVNPRQWAPE IVISGHFDGV QDLMWDPEGE FIITTSTDQT TRLFAPWKKK 420
DQKDRSQVTW HEIARPQIHG YNIKCLAMID RFQFVSGADE KVLRVFSAPR NFVENFSVIS 480
RQSLSHMLCD DQDLPEGATV PALGLSNKAL FQGDIASQPF EEDELISPAF GSPQVTFQPA 540
VLNEPPTEDH LLQNTLWPEI QKLYGHGYEI VCVACNNSKT LLASACKASQ KEHAAIILWS 600
TASWKQVQSL AFHTLTVTQM TFSPDDKFLL AVSRDRTWSL WKRQDATSSE FDPFFSLFAF 660
TNKITSVHSR IIWSCDWSPD NKYFFTGSRD KKVVVWGECK SSHNPMEHPI RPCSSILDVG 720
SSVTAVSVCP VLNPAQRYIV AIGLESGKIC IYSWNKTNQE INDWTSCVET NPSQSHSLGI 780
RRLCWKSCSD DDDDDDDDDT EQSEEGPEWL HFASCGEDHT VKIYRVNRRA L 831 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0033588; C:Elongator holoenzyme complex; ISS:UniProtKB.
 GO:0000502; C:proteasome complex; ISS:UniProtKB.
 GO:0008023; C:transcription elongation factor complex; ISO:MGI.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
 GO:0019901; F:protein kinase binding; IDA:MGI.
 GO:0043248; P:proteasome assembly; ISS:UniProtKB.
 GO:0046425; P:regulation of JAK-STAT cascade; IDA:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:UniProtKB. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS