| Tag | Content |
|---|
| CPLM ID | CPLM-005158 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase BUR1 |
Protein Synonyms/Alias | Bypass UAS requirement protein 1; Suppressor of GPA1-Vall50 mutation protein 1 |
Gene Name | SGV1 |
Gene Synonyms/Alias | BUR1; YPR161C; P9584.8 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 414 | PRGHIVEKGESPVVK | acetylation | [1] | | 421 | KGESPVVKNLGAIPR | acetylation | [1] | | 523 | PETNVSSKYNKVPLP | acetylation | [1] | | 563 | HNPRYVNKPETNFNR | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Serine/threonine-protein kinase component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates 'Ser-120' of the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B, the localization of the PAF1 complex to the chromatin, and the silencing of telomeric-associated genes. Also required for histone H3 'Lys-4' trimethylation. May phosphorylate the 'Ser-5' of the RBP1 carboxy-terminal domain (CTD) repeats. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. |
Sequence Annotation | DOMAIN 60 366 Protein kinase.
NP_BIND 66 74 ATP (By similarity).
ACT_SITE 195 195 Proton acceptor (By similarity).
BINDING 89 89 ATP (By similarity).
MOD_RES 240 240 Phosphothreonine; by CAK.
MOD_RES 405 405 Phosphothreonine.
MOD_RES 417 417 Phosphoserine.
MOD_RES 634 634 Phosphoserine. |
Keyword | ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 657 AA |
Protein Sequence | MSDNGSPAVL PKTEFNKYKI GKVKSTPAIQ RDAKTNLTYI KLRKRSSEKV YGCTVFQNHY 60
REDEKLGQGT FGEVYKGIHL ETQRQVAMKK IIVSVEKDLF PITAQREITI LKRLNHKNII 120
KLIEMVYDHS PDITNAASSN LHKSFYMILP YMVADLSGVL HNPRINLEMC DIKNMMLQIL 180
EGLNYIHCAK FMHRDIKTAN ILIDHNGVLK LADFGLARLY YGCPPNLKYP GGAGSGAKYT 240
SVVVTRWYRA PELVLGDKQY TTAVDIWGVG CVFAEFFEKK PILQGKTDID QGHVIFKLLG 300
TPTEEDWAVA RYLPGAELTT TNYKPTLRER FGKYLSETGL DFLGQLLALD PYKRLTAMSA 360
KHHPWFKEDP LPSEKITLPT EESHEADIKR YKEEMHQSLS QRVPTAPRGH IVEKGESPVV 420
KNLGAIPRGP KKDDASFLPP SKNVLAKPPP SKIRELHQNP RPYHVNSGYA KTAIPPPAAP 480
AGVNRYGPNN SSRNNRFSGN STAPNNSRNP VNRFHPETNV SSKYNKVPLP LGPQSRYQGN 540
SNESRYKNSP NDSRYHNPRY VNKPETNFNR QPQKYSRQES NAPINKNYNP SNGSRNMAGD 600
HHQGSRPSHP QFPISPSQGQ HQLTSKPIEK KNGSFKDERA KPDESKEFQN SDIADLY 657 |
Gene Ontology | GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:SGD. GO:0005634; C:nucleus; IPI:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IPI:SGD. GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IDA:SGD. GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IDA:SGD. GO:0051571; P:positive regulation of histone H3-K4 methylation; IMP:SGD. GO:0006351; P:transcription, DNA-dependent; IDA:SGD. |
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