UniProt Accession

 TRM61_HUMAN; Q96FX7; A6NN78; Q8N7Q9 

Genbank Protein ID

 AL133367; AL139300; BC010167; AK097771 

Genbank Nucleotide ID

 AAH10167.1; BAC05168.1 

Protein Name

 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 

Protein Synonyms/Alias

 tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRMT61A 

Gene Name

 TRMT61A 

Gene Synonyms/Alias

 C14orf172; TRM61 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	IGRPFGSKVTCGRGG	acetylation	[1]
57	IGRPFGSKVTCGRGG	ubiquitination	[2, 3]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. 

Sequence Annotation

 BINDING 114 114 S-adenosyl-L-methionine (By similarity).
 BINDING 135 135 S-adenosyl-L-methionine (By similarity).
 BINDING 163 163 S-adenosyl-L-methionine (By similarity).
 BINDING 181 181 S-adenosyl-L-methionine (By similarity).
 MOD_RES 263 263 Phosphoserine.  

Keyword

 Complete proteome; Methyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0031515; C:tRNA (m1A) methyltransferase complex; IEA:InterPro.
 GO:0016429; F:tRNA (adenine-N1-)-methyltransferase activity; IEA:InterPro. 

Interpro

 IPR014816; tRNA_MeTrfase_GCD14.
 IPR025809; tRNA_MeTrfase_GCD14_euk. 

Pfam

 PF08704; GCD14 

SMART

  

PROSITE

  

PRINTS