CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043347
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytochrome b-c1 complex subunit 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 UQCRC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38SRIGLFIKAGSRYEDubiquitination[1, 2]
64LTSSLTTKGASSFKIubiquitination[1, 2]
70TKGASSFKITRGIEAubiquitination[1]
81GIEAVGGKLSVTATRubiquitination[2]
131ADLQPQLKIDKAVAFacetylation[3]
131ADLQPQLKIDKAVAFubiquitination[1, 2, 4]
134QPQLKIDKAVAFQNPubiquitination[1, 2, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 176 AA 
Protein Sequence
MKLLTRAGSF SFTKLPNGLV IASLENYSPV SRIGLFIKAG SRYEDFSNLG TTHLLRLTSS 60
LTTKGASSFK ITRGIEAVGG KLSVTATREN MAYTVECLRG DVDILMEFLL NVTTAPEFRR 120
WEVADLQPQL KIDKAVAFQN PQTHVIENLH AAAYRNALAN PLYCPDYRIG KVTSEE 176 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR011249; Metalloenz_LuxS/M16.
 IPR011237; Pept_M16_dom.
 IPR011765; Pept_M16_N.
 IPR001431; Pept_M16_Zn_BS. 
Pfam
 PF00675; Peptidase_M16 
SMART
  
PROSITE
 PS00143; INSULINASE 
PRINTS