UniProt Accession

 UIF_HUMAN; Q96QD9; A8MY74; B2RCB2; B7Z3R4; B7Z7V1; B7Z8I0; B7ZAJ3; C9J7P6; C9JNG6; C9JTH3; C9JY50; Q96SL9; Q9BQI8 

Genbank Protein ID

 AJ344094; AL136558; AK027672; AK296283; AK302546; AK303462; AK315019; AK316308; CR533502; AC024560; AC055764; CH471252; BC035006; BC039734 

Genbank Nucleotide ID

 CAC51432.1; CAB66493.1; BAB55284.1; BAH12300.1; BAH13737.1; BAH13966.1; BAG37509.1; BAH14679.1; CAG38533.1; EAW92240.1; AAH35006.1; AAH39734.1 

Protein Name

 UAP56-interacting factor 

Protein Synonyms/Alias

 Forty-two-three domain-containing protein 1; Protein 40-2-3 

Gene Name

 FYTTD1 

Gene Synonyms/Alias

 UIF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
140	YFPVLKRKANLLRQN	sumoylation	[1]
166	RPSQLSRKNNIPANF	ubiquitination	[2]
215	LLDDVVAKRTRQWRT	ubiquitination	[2]
261	AVPSFLTKREQSDVK	ubiquitination	[2]
299	NERFGILKEQRATLT	ubiquitination	[2]
309	RATLTYNKGGSRFVT	ubiquitination	[2]

Reference

 [1] In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.
 Blomster HA, Imanishi SY, Siimes J, Kastu J, Morrice NA, Eriksson JE, Sistonen L.
 J Biol Chem. 2010 Jun 18;285(25):19324-9. [PMID: 20388717]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. 

Sequence Annotation

 MOTIF 26 44 UAP56-binding motif.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 23 23 Phosphoserine.
 CROSSLNK 140 140 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Isopeptide bond; mRNA transport; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0016607; C:nuclear speck; IDA:UniProtKB.
 GO:0003729; F:mRNA binding; IDA:UniProtKB.
 GO:0006406; P:mRNA export from nucleus; IMP:UniProtKB. 

Interpro

 IPR009782; DUF1346. 

Pfam

 PF07078; FYTT 

SMART

  

PROSITE

  

PRINTS