CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021836
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transferrin receptor protein 2 
Protein Synonyms/Alias
 TfR2 
Gene Name
 Tfr2 
Gene Synonyms/Alias
 Trfr2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
177LVQDILDKLSRQKLDubiquitination[1]
685RAAEKLRKEIYSSERubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. 
Sequence Annotation
 MOTIF 23 26 Endocytosis signal (Potential).
 CARBOHYD 235 235 N-linked (GlcNAc...) (Potential).
 CARBOHYD 334 334 N-linked (GlcNAc...) (Potential).
 CARBOHYD 535 535 N-linked (GlcNAc...) (Potential).
 DISULFID 106 106 Interchain (Potential).
 DISULFID 109 109 Interchain (Potential).  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 798 AA 
Protein Sequence
MEQRWGLLRR VQQWSPRPSQ TIYRRVEGPQ LEHLEEEDRE EGAELPAQFC PMELKGPEHL 60
GSCPGRSIPI PWAAAGRKAA PYLVLITLLI FTGAFLLGYV AFRGSCQACG DSVLVVDEDV 120
NPEDSGRTTL YWSDLQAMFL RFLGEGRMED TIRLTSLRER VAGSARMATL VQDILDKLSR 180
QKLDHVWTDT HYVGLQFPDP AHANTLHWVD ADGSVQEQLP LEDPEVYCPY SATGNATGKL 240
VYAHYGRSED LQDLKAKGVE LAGSLLLVRV GITSFAQKVA VAQDFGAQGV LIYPDPSDFS 300
QDPHKPGLSS HQAVYGHVHL GTGDPYTPGF PSFNQTQFPP VESSGLPSIP AQPISADIAD 360
QLLRKLTGPV APQEWKGHLS GSPYRLGPGP DLRLVVNNHR VSTPISNIFA CIEGFAEPDH 420
YVVIGAQRDA WGPGAAKSAV GTAILLELVR TFSSMVSNGF RPRRSLLFIS WDGGDFGSVG 480
ATEWLEGYLS VLHLKAVVYV SLDNSVLGDG KFHAKTSPLL VSLIENILKQ VDSPNHSGQT 540
LYEQVALTHP SWDAEVIQPL PMDSSAYSFT AFAGVPAVEF SFMEDDRVYP FLHTKEDTYE 600
NLHKMLRGRL PAVVQAVAQL AGQLLIRLSH DHLLPLDFGR YGDVVLRHIG NLNEFSGDLK 660
ERGLTLQWVY SARGDYIRAA EKLRKEIYSS ERNDERLMRM YNVRIMRVEF YFLSQYVSPA 720
DSPFRHIFLG QGDHTLGALV DHLRMLRADG SGAASSRLTA GLGFQESRFR RQLALLTWTL 780
QGAANALSGD VWNIDNNF 798 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; ISA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008233; F:peptidase activity; IEA:InterPro.
 GO:0004998; F:transferrin receptor activity; TAS:MGI.
 GO:0006879; P:cellular iron ion homeostasis; TAS:MGI.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR007484; Peptidase_M28.
 IPR003137; Protease-assoc_domain.
 IPR007365; TFR-like_dimer_dom. 
Pfam
 PF02225; PA
 PF04389; Peptidase_M28
 PF04253; TFR_dimer 
SMART
  
PROSITE
  
PRINTS