CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014990
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyrin and HIN domain-containing protein 1 
Protein Synonyms/Alias
 Interferon-inducible protein X 
Gene Name
 PYHIN1 
Gene Synonyms/Alias
 IFIX 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
40LKLNPKMKEEYDKIQacetylation[1]
45KMKEEYDKIQIADLMacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. 
Sequence Annotation
 DOMAIN 1 88 DAPIN.
 DOMAIN 199 399 HIN-200.  
Keyword
 Alternative splicing; Cell cycle; Complete proteome; Nucleus; Reference proteome; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 492 AA 
Protein Sequence
MANNYKKIVL LKGLEVINDY HFRIVKSLLS NDLKLNPKMK EEYDKIQIAD LMEEKFPGDA 60
GLGKLIEFFK EIPTLGDLAE TLKREKLKVA NKIESIPVKG IIPSKKTKQK EVYPATPACT 120
PSNRLTAKGA EETLGPQKRK KPSEEETGTK RSKMSKEQTR PSCSAGASTS TAMGRSPPPQ 180
TSSSAPPNTS STESLKPLAN RHATASKNIF REDPIIAMVL NATKVFKYES SENEQRRMFH 240
ATVATQTQFF HVKVLNINLK RKFIKKRIII ISNYSKRNSL LEVNEASSVS EAGPDQTFEV 300
PKDIIRRAKK IPKINILHKQ TSGYIVYGLF MLHTKIVNRK TTIYEIQDKT GSMAVVGKGE 360
CHNIPCEKGD KLRLFCFRLR KRENMSKLMS EMHSFIQIQK NTNQRSHDSR SMALPQEQSQ 420
HPKPSEASTT LPESHLKTPQ MPPTTPSSSS FTKKDETHPG AQSSPANFRI TSPTVAPPLS 480
SDTSTNRHPA VP 492 
Gene Ontology
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW. 
Interpro
 IPR004020; DAPIN.
 IPR004021; HIN200/IF120x.
 IPR012340; NA-bd_OB-fold. 
Pfam
 PF02760; HIN
 PF02758; PYRIN 
SMART
  
PROSITE
 PS50824; DAPIN
 PS50834; HIN_200 
PRINTS