| Tag | Content |
|---|
| CPLM ID | CPLM-003791 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MLV-related proviral Env polyprotein |
Protein Synonyms/Alias | Surface protein; SU; Transmembrane protein; TM |
Gene Name | |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 151 | SWDLISLKRRNTPQN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane (By similarity). |
Sequence Annotation | REGION 443 463 Fusion peptide (By similarity).
REGION 509 525 Immunosuppression (By similarity).
MOTIF 307 310 CXXC (By similarity).
MOTIF 526 534 CX6CC (By similarity).
MOTIF 626 629 YXXL motif; contains endocytosis signal
LIPID 601 601 S-palmitoyl cysteine (By similarity).
CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
CARBOHYD 297 297 N-linked (GlcNAc...) (Potential).
CARBOHYD 336 336 N-linked (GlcNAc...) (Potential).
CARBOHYD 369 369 N-linked (GlcNAc...) (Potential).
DISULFID 109 126 By similarity.
DISULFID 118 131 By similarity.
DISULFID 307 534 Interchain (between SU and TM chains, or
DISULFID 307 310 Alternate (By similarity).
DISULFID 337 391 By similarity.
DISULFID 356 368 By similarity.
DISULFID 398 411 By similarity.
DISULFID 526 533 By similarity. |
Keyword | Cell membrane; Cleavage on pair of basic residues; Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Lipoprotein; Membrane; Metal-binding; Palmitate; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Viral envelope protein; Virion; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 641 AA |
Protein Sequence | MEGPAFSKPL KDKINPWGPL IVLGILIRAG VSVQHDSPHQ VFNVTWRVTN LMTGQTANAT 60
SLLGTMTDAF PKLYFDLCDL IGDDWDETGL GCRTPGGRKR ARTFDFYVCP GHTVPTGCGG 120
PREGYCGKWG CETTGQAYWK PSSSWDLISL KRRNTPQNQG PCYDSSAVSS DIKGATPGGR 180
CNPLVLEFTD AGKKASWDGP KVWGLRLYRS TGTDPVTRFS LTRQVLNIGP RVPIGPNPVI 240
TDQLPPSRPV QIMLPRPPQP PPPGAASIVP ETAPPSQQPG TGDRLLNLVD GAYQALNLTS 300
PDKTQECWLC LVAGPPYYEG VAVLGTYSNH TSAPANCSVA SQHKLTLSEV TGQGLCVGAV 360
PKTHQALCNT TQKTSDGSYY LAAPAGTIWA CNTGLTPCLS TTVLDLTTDY CVLVELWPKV 420
TYHSPGYVYG QFERKTKYKR EPVSLTLALL LGGLTMGGIA AGVGTGTTAL VATKQFEQLQ 480
AAIHTDLGAL EKSVSALEKS LTSLSEVVLQ NRRGLDLLFL KEGGLCAALK EECCFYADHT 540
GVVRDSMAKL RERLNQRQKL FESGQGWFEG LFNRSPWFTT LISTIMGPLI ILLLILLFGP 600
CILNRLVQFV KDRISVVQAL VLTQQYHQLK SIDPEEVESR E 641 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0019028; C:viral capsid; IEA:InterPro. GO:0019031; C:viral envelope; IEA:UniProtKB-KW. GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0019058; P:viral infectious cycle; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |