CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009310
UniProt Accession
Genbank Protein ID
 M83680 
Genbank Nucleotide ID
Protein Name
 Ras-related protein Rab-14 
Protein Synonyms/Alias
  
Gene Name
 Rab14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
170DAFLEAAKKIYQNIQubiquitination[1]
193AESGVQHKPSAPQGGubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. 
Sequence Annotation
 NP_BIND 18 26 GTP (Probable).
 NP_BIND 66 70 GTP (Probable).
 NP_BIND 124 127 GTP (Probable).
 NP_BIND 154 156 GTP (By similarity).
 MOTIF 40 48 Effector region (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 98 98 Phosphothreonine (By similarity).
 MOD_RES 99 99 Phosphotyrosine (By similarity).
 MOD_RES 215 215 Cysteine methyl ester (By similarity).
 LIPID 213 213 S-geranylgeranyl cysteine (By
 LIPID 215 215 S-geranylgeranyl cysteine (By  
Keyword
 Acetylation; Complete proteome; Cytoplasmic vesicle; Endosome; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 215 AA 
Protein Sequence
MATTPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT RIIEVSGQKI 60
KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN HLSSWLTDAR NLTNPNTVII 120
LIGNKADLEA QRDVTYEEAK QFAEENGLLF LEASAKTGEN VEDAFLEAAK KIYQNIQDGS 180
LDLNAAESGV QHKPSAPQGG RLTSEPQPQR EGCGC 215 
Gene Ontology
 GO:0097208; C:alveolar lamellar body; IDA:RGD.
 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005795; C:Golgi stack; IDA:UniProtKB.
 GO:0005770; C:late endosome; IDA:UniProtKB.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0042175; C:nuclear outer membrane-endoplasmic reticulum membrane network; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0055037; C:recycling endosome; ISS:UniProtKB.
 GO:0005791; C:rough endoplasmic reticulum; IDA:UniProtKB.
 GO:0030140; C:trans-Golgi network transport vesicle; IDA:UniProtKB.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0001948; F:glycoprotein binding; IDA:RGD.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0045176; P:apical protein localization; IDA:RGD.
 GO:0007589; P:body fluid secretion; IMP:RGD.
 GO:0009790; P:embryo development; ISS:UniProtKB.
 GO:0032456; P:endocytic recycling; ISS:UniProtKB.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0006895; P:Golgi to endosome transport; ISS:UniProtKB.
 GO:0007269; P:neurotransmitter secretion; NAS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0032880; P:regulation of protein localization; IDA:RGD.
 GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.