| Tag | Content |
|---|
| CPLM ID | CPLM-005325 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SCF E3 ubiquitin ligase complex F-box protein GRR1 |
Protein Synonyms/Alias | F-box and leucine-rich repeat protein GRR1; F-box/LRR-repeat protein GRR1 |
Gene Name | GRR1 |
Gene Synonyms/Alias | CAT80; COT2; YJR090C; J1885 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 567 | NLFQELSKVVDDMPS | ubiquitination | [1] | | 622 | ASLFQLSKLGKNLQT | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2. Probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression. |
Sequence Annotation | DOMAIN 314 361 F-box.
REPEAT 399 423 LRR 1.
REPEAT 424 449 LRR 2.
REPEAT 450 475 LRR 3.
REPEAT 476 501 LRR 4.
REPEAT 502 527 LRR 5.
REPEAT 528 553 LRR 6.
REPEAT 554 582 LRR 7.
REPEAT 583 608 LRR 8.
REPEAT 609 634 LRR 9.
REPEAT 635 660 LRR 10.
REPEAT 661 685 LRR 11.
REPEAT 686 714 LRR 12.
REPEAT 715 740 LRR 13.
MOD_RES 199 199 Phosphoserine.
MOD_RES 300 300 Phosphoserine. |
Keyword | Carbohydrate metabolism; Complete proteome; Glucose metabolism; Leucine-rich repeat; Membrane; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1151 AA |
Protein Sequence | MDQDNNNHND SNRLHPPDIH PNLGPQLWLN SSGDFDDNNN NNNNNNNNNS TRPQMPSRTR 60
ETATSERNAS EVRDATLNNI FRFDSIQRET LLPTNNGQPL NQNFSLTFQP QQQTNALNGI 120
DINTVNTNLM NGVNVQIDQL NRLLPNLPEE ERKQIHEFKL IVGKKIQEFL VVIEKRRKKI 180
LNEIELDNLK LKELRIDNSP QAISYLHKLQ RMRLRALETE NMEIRNLRLK ILTIIEEYKK 240
SLYAYCHSKL RGQQVENPTD NFIIWINSID TTESSDLKEG LQDLSRYSRQ FINNVLSNPS 300
NQNICTSVTR RSPVFALNML PSEILHLILD KLNQKYDIVK FLTVSKLWAE IIVKILYYRP 360
HINKKSQLDL FLRTMKLTSE ETVFNYRLMI KRLNFSFVGD YMHDTELNYF VGCKNLERLT 420
LVFCKHITSV PISAVLRGCK FLQSVDITGI RDVSDDVFDT LATYCPRVQG FYVPQARNVT 480
FDSLRNFIVH SPMLKRIKIT ANNNMNDELV ELLANKCPLL VEVDITLSPN VTDSSLLKLL 540
TRLVQLREFR ITHNTNITDN LFQELSKVVD DMPSLRLIDL SGCENITDKT IESIVNLAPK 600
LRNVFLGKCS RITDASLFQL SKLGKNLQTV HFGHCFNITD NGVRALFHSC TRIQYVDFAC 660
CTNLTNRTLY ELADLPKLKR IGLVKCTQMT DEGLLNMVSL RGRNDTLERV HLSYCSNLTI 720
YPIYELLMSC PRLSHLSLTA VPSFLRPDIT MYCRPAPSDF SENQRQIFCV FSGKGVHKLR 780
HYLVNLTSPA FGPHVDVNDV LTKYIRSKNL IFNGETLEDA LRRIITDLNQ DSAAIIAATG 840
LNQINGLNND FLFQNINFER IDEVFSWYLN TFDGIRMSSE EVNSLLLQVN KTFCEDPFSD 900
VDDDQDYVVA PGVNREINSE MCHIVRKFHE LNDHIDDFEV NVASLVRVQF QFTGFLLHEM 960
TQTYMQMIEL NRQICLVQKT VQESGNIDYQ KGLLIWRLLF IDKFIMVVQK YKLSTVVLRL 1020
YLKDNITLLT RQRELLIAHQ RSAWNNNNDN DANRNANNIV NIVSDAGAND TSNNETNNGN 1080
DDNETENPNF WRQFGNRMQI SPDQMRNLQM GLRNQNMVRN NNNNTIDESM PDTAIDSQMD 1140
EASGTPDEDM L 1151 |
Gene Ontology | GO:0000142; C:cellular bud neck contractile ring; IDA:SGD. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:SGD. GO:0019005; C:SCF ubiquitin ligase complex; IMP:SGD. GO:0030674; F:protein binding, bridging; IDA:SGD. GO:0000751; P:cell cycle arrest in response to pheromone; IMP:SGD. GO:0071406; P:cellular response to methylmercury; IMP:SGD. GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:SGD. GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; IGI:SGD. GO:0006974; P:response to DNA damage stimulus; IMP:SGD. GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IPI:SGD. |
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