UniProt Accession

 ACADS_HUMAN; P16219; P78331 

Genbank Protein ID

 M26393; Z80345; Z80347; U83992; U83991; BC025963 

Genbank Nucleotide ID

 AAA60307.1; CAB02492.1; CAB02492.1; AAD00552.1; AAD00552.1; AAH25963.1 

Protein Name

 Short-chain specific acyl-CoA dehydrogenase, mitochondrial 

Protein Synonyms/Alias

 SCAD; Butyryl-CoA dehydrogenase 

Gene Name

 ACADS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
306	AFGAPLTKLQVIQFK	acetylation	[1]
306	AFGAPLTKLQVIQFK	ubiquitination	[2]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 NP_BIND 152 161 FAD.
 NP_BIND 185 187 FAD.
 NP_BIND 365 369 FAD; shared with dimeric partner.
 NP_BIND 394 396 FAD.
 REGION 269 272 Substrate binding.
 ACT_SITE 392 392 Proton acceptor (By similarity).
 BINDING 161 161 Substrate; via carbonyl oxygen.
 BINDING 297 297 FAD; shared with dimeric partner.
 BINDING 308 308 FAD.
 BINDING 393 393 Substrate; via amide nitrogen.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0031966; C:mitochondrial membrane; IEA:Compara.
 GO:0003995; F:acyl-CoA dehydrogenase activity; TAS:Reactome.
 GO:0004085; F:butyryl-CoA dehydrogenase activity; IEA:EC.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0046359; P:butyrate catabolic process; IEA:Compara.
 GO:0006635; P:fatty acid beta-oxidation; TAS:Reactome.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara. 

Interpro

 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 

Pfam

 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 

SMART

  

PROSITE

 PS00072; ACYL_COA_DH_1
 PS00073; ACYL_COA_DH_2 

PRINTS