UniProt Accession

 B2L12_HUMAN; Q9HB09; Q3SY11; Q3SY13; Q96I96; Q9HB08 

Genbank Protein ID

 AF289220; AF289220; AC011495; BC007724; BC104004; BC104005; BC104006 

Genbank Nucleotide ID

 AAG29495.1; AAG29496.1; AAH07724.2; AAI04005.1; AAI04006.1; AAI04007.1 

Protein Name

 Bcl-2-like protein 12 

Protein Synonyms/Alias

 Bcl2-L-12; Bcl-2-related proline-rich protein 

Gene Name

 BCL2L12 

Gene Synonyms/Alias

 BPR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
191	QLVQEQLKSPPSPEL	ubiquitination	[1, 2, 3]
206	QGPPSTEKEAILRRL	ubiquitination	[3]
227	EAEVINQKLASDPAL	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

  

Sequence Annotation

 MOTIF 311 322 BH2.
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 117 117 Phosphothreonine.
 MOD_RES 121 121 Phosphoserine.
 MOD_RES 242 242 Phosphoserine.
 MOD_RES 243 243 Phosphoserine.  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

PROSITE

 PS01258; BH2 

PRINTS