CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012065
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metastasis-associated protein MTA1 
Protein Synonyms/Alias
  
Gene Name
 MTA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32RRIEELNKTANGNVEubiquitination[1, 2, 3]
125PATHIRGKCSVTLLNubiquitination[3]
208AHNPLTDKQIDQFLVubiquitination[1, 4]
260HAMDTLHKNIYDISKubiquitination[4]
361VYIPNYNKPNPNQISubiquitination[4]
509PINSAAIKAECTARLsumoylation[5]
527SQSPLVLKQAVRKPLubiquitination[2, 3, 4]
582GSPTILGKRSYEQHNubiquitination[3]
626RNLLLNGKSYPTKVRacetylation[6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.
 Cong L, Pakala SB, Ohshiro K, Li DQ, Kumar R.
 J Biol Chem. 2011 Dec 23;286(51):43793-808. [PMID: 21965678]
 [6] MTA1, a transcriptional activator of breast cancer amplified sequence 3.
 Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R.
 Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6670-5. [PMID: 16617102
Functional Description
 May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER. 
Sequence Annotation
 DOMAIN 1 164 BAH.
 DOMAIN 165 276 ELM2.
 DOMAIN 283 335 SANT.
 ZN_FING 393 420 GATA-type; atypical.
 MOTIF 545 552 SH3-binding (Potential).
 MOTIF 696 705 SH3-binding (Potential).
 MOD_RES 386 386 Phosphoserine.
 MOD_RES 446 446 Phosphoserine.
 MOD_RES 449 449 Phosphoserine.
 MOD_RES 522 522 Phosphoserine.
 MOD_RES 564 564 Phosphothreonine.
 MOD_RES 576 576 Phosphoserine.
 MOD_RES 578 578 Phosphothreonine.
 MOD_RES 639 639 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 715 AA 
Protein Sequence
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD ISSTLIALAD 60
KHATLSVCYK AGPGADNGEE GEIEEEMENP EMVDLPEKLK HQLRHRELFL SRQLESLPAT 120
HIRGKCSVTL LNETESLKSY LEREDFFFYS LVYDPQQKTL LADKGEIRVG NRYQADITDL 180
LKEGEEDGRD QSRLETQVWE AHNPLTDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM 240
SAAAASRDIT LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL 300
EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK LKQVYIPNYN 360
KPNPNQISVN NVKAGVVNGT GAPGQSPGAG RACESCYTTQ SYQWYSWGPP NMQCRLCASC 420
WTYWKKYGGL KMPTRLDGER PGPNRSNMSP HGLPARSSGS PKFAMKTRQA FYLHTTKLTR 480
IARRLCREIL RPWHAARHPY LPINSAAIKA ECTARLPEAS QSPLVLKQAV RKPLEAVLRY 540
LETHPRPPKP DPVKSVSSVL SSLTPAKVAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL 600
MPSRGLANHG QARHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM 660
ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPPRP PPPAPVNDEP IVIED 715 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016581; C:NuRD complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0033363; P:secretory granule organization; IEA:Compara.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR001025; BAH_dom.
 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR000679; Znf_GATA. 
Pfam
 PF01426; BAH
 PF01448; ELM2
 PF00320; GATA 
SMART
 SM00439; BAH
 SM00717; SANT
 SM00401; ZnF_GATA 
PROSITE
 PS51038; BAH
 PS51156; ELM2
 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2
 PS51293; SANT 
PRINTS