UniProt Accession

 TIPRL_MOUSE; Q8BH58 

Genbank Protein ID

 AK049119; AK049784; AK075774; BC002098; BC058250 

Genbank Nucleotide ID

 BAC33553.1; BAC33919.1; BAC35948.1; AAH02098.1; AAH58250.1 

Protein Name

 TIP41-like protein 

Protein Synonyms/Alias

  

Gene Name

 Tiprl 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
117	WTYTTDYKGTLLGES	ubiquitination	[1]
128	LGESLKLKVVPTTDH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity). 

Sequence Annotation

 REGION 173 271 Interaction with PPP2CA (By similarity).
 MOD_RES 106 106 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000077; P:DNA damage checkpoint; IEA:Compara.
 GO:0034048; P:negative regulation of protein phosphatase type 2A activity; IEA:Compara. 

Interpro

 IPR007303; TIP41-like. 

Pfam

 PF04176; TIP41 

SMART

  

PROSITE

  

PRINTS