CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029229
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Crystallin, lamda 1, isoform CRA_a 
Protein Synonyms/Alias
 L-gulonate 3-dehydrogenase 
Gene Name
 Cryl1 
Gene Synonyms/Alias
 gul3dh; mCG_127036 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
33ASGGFKVKLYDIEQQubiquitination[1]
54ENIRKEMKSLEQSGSubiquitination[1]
63LEQSGSLKGSLSAERubiquitination[1]
287VSEDMCMKVPDDPEHubiquitination[1]
308WRDDCLMKLSILKYQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Oxidoreductase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 319 AA 
Protein Sequence
MASPAAGGVV IVGSGLIGRS WAMLFASGGF KVKLYDIEQQ QITDALENIR KEMKSLEQSG 60
SLKGSLSAER QLSLISGCGN LAEAVEGAVH IQECVPENLE LKKKIFAQLD RIVDDRVILS 120
SSSSCLLPSK LFSGLAHVKQ CIVAHPVNPP YYVPLVELVP HPETAPATMD RTYALMKKIG 180
QSPVRVLKEI DGFVLNRLQY AVISEAWRLV EEEIVSPSDL DLVMSDGLGM RYAFIGPLET 240
MHLNAEGVIS YCERYSEGMK HVLSTFGPVP EFSGATVERV SEDMCMKVPD DPEHLAARRQ 300
WRDDCLMKLS ILKYQMQPK 319 
Gene Ontology
 GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050104; F:L-gulonate 3-dehydrogenase activity; IEA:EC.
 GO:0070403; F:NAD+ binding; IEA:Compara.
 GO:0006631; P:fatty acid metabolic process; IEA:InterPro. 
Interpro
 IPR022694; 3-OHacyl-CoA_DH.
 IPR006180; 3-OHacyl-CoA_DH_CS.
 IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
 IPR006108; 3HC_DH_C.
 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00725; 3HCDH
 PF02737; 3HCDH_N 
SMART
  
PROSITE
 PS00067; 3HCDH 
PRINTS