CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034387
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-binding cassette sub-family B member 8, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Abcb8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
228DIAFFDAKKTGQLVSacetylation[1]
245TTDVQEFKSSFKLVIacetylation[2, 3]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MLVHLFRFGI RGGPVPGWSL QSLRFQTFSA ARSSDDRLSS HLLRTVAQLR VQLRAHLPRA 60
PPASHWSPSA WCWVGGTLVV PAVLWQHPRL CLIALCEAKE SPPAQPTRAP ELRFNWKLFW 120
HFLHPHLLAL GAAIVLALGA ALVNVQIPLL LGQLVEIVAK YTRDHMGSFV SESRKLSVQL 180
LLLYGVQGLL TFGYLVLLSH IGERMAMDMR KALFSSLLRQ DIAFFDAKKT GQLVSRLTTD 240
VQEFKSSFKL VISQGLRSCT QVIGSLVSLS MLSPRLTLML AVVTPALMGV GTLMGSGLRK 300
LSRQCQEQIA RATGVADEAL GNVRTVRAFA MEKREEERYQ AELESCCCKA EELGRGIALF 360
QGLSNIAFNC MVLGTLFIGG SLVAGQQLKG GDLMSFLVAS QTVQRLFQGC PGLRAFQG 418 
Gene Ontology
 GO:0016021; C:integral to membrane; IBA:RefGenome.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:RefGenome. 
Interpro
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1. 
Pfam
 PF00664; ABC_membrane 
SMART
  
PROSITE
 PS50929; ABC_TM1F 
PRINTS