UniProt Accession

 CLP1L_HUMAN; Q96KA5; D3DTC1; Q658W6; Q7LG29; Q96AZ0; Q9H3N4 

Genbank Protein ID

 AK027306; CH471102; CH471102; BC016399; BC025305; AB045223; AL832953 

Genbank Nucleotide ID

 BAB55030.1; EAX08162.1; EAX08163.1; AAH16399.1; AAH25305.1; BAB20083.1; CAH56333.1 

Protein Name

 Cleft lip and palate transmembrane protein 1-like protein 

Protein Synonyms/Alias

 CLPTM1-like protein; Cisplatin resistance-related protein 9; CRR9p 

Gene Name

 CLPTM1L 

Gene Synonyms/Alias

 CRR9 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
85	EDFDVESKFERTVNV	ubiquitination	[1]
199	ADVHRYMKMIQLGKT	ubiquitination	[1, 2, 3, 4]
205	MKMIQLGKTVHYLPI	ubiquitination	[3]
223	DQLSNRVKDLMVINR	ubiquitination	[3]
243	PLTVSYDKVSLGRLR	ubiquitination	[1, 2, 3, 4, 5]
316	ISFWKKKKSMIGMST	ubiquitination	[1, 3]
324	SMIGMSTKAVLWRCF	ubiquitination	[6]
459	LFVNYKLKSVAHLPW	ubiquitination	[2, 4]
467	SVAHLPWKAFTYKAF	ubiquitination	[2, 3, 4, 7]
517	RWLYPVDKRRVNEFG	ubiquitination	[1, 3]
530	FGESYEEKATRAPHT	ubiquitination	[1, 3, 4, 8]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [8] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 

Functional Description

 Enhances cisplatin-mediated apoptosis, when overexpressed. 

Sequence Annotation

 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 CARBOHYD 229 229 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 538 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. 

Interpro

 IPR008429; CLPTM1. 

Pfam

 PF05602; CLPTM1 

SMART

  

PROSITE

  

PRINTS