| Tag | Content |
|---|
| CPLM ID | CPLM-000599 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Retinal-specific ATP-binding cassette transporter |
Protein Synonyms/Alias | ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP |
Gene Name | Abca4 |
Gene Synonyms/Alias | Abcr |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 683 | LEKELRLKETLKNQG | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery (By similarity). |
Sequence Annotation | DOMAIN 929 1160 ABC transporter 1.
DOMAIN 1937 2169 ABC transporter 2.
NP_BIND 963 970 ATP 1 (Potential).
NP_BIND 1971 1978 ATP 2 (Potential).
CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
CARBOHYD 415 415 N-linked (GlcNAc...) (Potential).
CARBOHYD 504 504 N-linked (GlcNAc...) (Potential).
CARBOHYD 1468 1468 N-linked (GlcNAc...) (Potential).
CARBOHYD 1528 1528 N-linked (GlcNAc...) (Potential).
CARBOHYD 1587 1587 N-linked (GlcNAc...) (Potential).
CARBOHYD 1661 1661 N-linked (GlcNAc...) (Potential).
DISULFID 75 324 By similarity.
DISULFID 1487 1501 By similarity. |
Keyword | ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Nucleotide-binding; Reference proteome; Repeat; Sensory transduction; Transmembrane; Transmembrane helix; Transport; Vision. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2310 AA |
Protein Sequence | MGFLRQIQLL LWKNWTLRKR QKIRFVVELV WPLSLFLVLI WLRNANPLYS QHECHFPNKA 60
MPSAGLLPWL QGIFCNMNNP CFQNPTPGES PGTVSNYNNS ILARVYRDFQ ELFMDTPEVQ 120
HLGQVWAELR TLSQFMDTLR THPERFAGRG LQIRDILKDE EALTLFLMRN IGLSDSVAHL 180
LVNSQVRVEQ FAYGVPDLEL TDIACSEALL QRFIIFSQRR GAQTVRDALC PLSQVTLQWI 240
EDTLYADVDF FKLFHVLPTL LDSSSQGINL RFWGGILSDL SPRMQKFIHR PSVQDLLWVS 300
RPLLQNGGPE TFTQLMSILS DLLCGYPEGG GSRVFSFNWY EDNNYKAFLG IDSTRKDPAY 360
SYDKRTTSFC NSLIQSLESN PLTKIAWRAA KPLLMGKILF TPDSPAARRI MKNANSTFEE 420
LDRVRKLVKA WEEVGPQIWY FFEKSTQMTV IRDTLQHPTV KDFINRQLGE EGITTEAVLN 480
FFSNGPQEKQ ADDMTSFDWR DIFNITDRFL RLANQYLECL VLDKFESYDD EVQLTQRALS 540
LLEENRFWAG VVFPGMYPWA SSLPPHVKYK IRMDIDVVEK TNKIKDRYWD SGPRADPVED 600
FRYIWGGFAY LQDMVEQGIV KSQMQAEPPI GVYLQQMPYP CFVDDSFMII LNRCFPIFMV 660
LAWIYSVSMT VKGIVLEKEL RLKETLKNQG VSNAVIWCTW FLDSFSIMAL SIFLLTLFIM 720
HGRILHYSDP FILFLFLLAF ATATIMQSFL LSTLFSKASL AAACSGVIYF TLYLPHVLCF 780
AWQDRMTADL KTTVSLLSSV AFGFGTEYLV RFEEQGLGLQ WSNIGKSPLE GDEFSFLLSM 840
KMMLLDAALY GLLAWYLDQV FPGDYGTPLP WYFLLQESYW LGGEGCSTRE ERALEKTEPL 900
TEEMEDPEHP EGMNDSFFER ELPGLVPGVC VKNLVKVFEP SGRPAVDRLN ITFYENQITA 960
FLGHNGAGKT TTLSILTGLL PPTSGTVLIG GKDIETNLDV VRQSLGMCPQ HNILFHHLTV 1020
AEHILFYAQL KGRSWEEAQL EMEAMLEDTG LHHKRNEEAQ DLSGGMQRKL SVAIAFVGDS 1080
KVVVLDEPTS GVDPYSRRSI WDLLLKYRSG RTIIMSTHHM DEADLLGDRI AIISQGRLYC 1140
SGTPLFLKNC FGTGFYLTLV RKMKNIQSQR GGCEGVCSCT SKGFSTRCPT RVDEITEEQV 1200
LDGDVQELMD LVYHHVPEAK LVECIGQELI FLLPNKNFKQ RAYASLFREL EETLADLGLS 1260
SFGISDTPLE EIFLKVTEDA GAGSMFVGGA QQKREQAGLR HPCSAPTEKL RQYAQAPHTC 1320
SPGQVDPPKG QPSPEPEDPG VPFNTGARLI LQHVQALLVK RFHHTIRSRK DFVAQIVLPA 1380
TFVFLALMLS IIVPPFGEFP ALTLHPWMYG HQYTFFSMDE PNNEHLEVLA DVLLNRPGFG 1440
NRCLKEEWLP EYPCINATSW KTPSVSPNIT HLFQKQKWTA AHPSPSCKCS TREKLTMLPE 1500
CPEGAGGLPP PQRTQRSTEV LQDLTNRNIS DYLVKTYPAL IRSSLKSKFW VNEQRYGGIS 1560
IGGKLPAIPI SGEALVGFLS GLGQMMNVSG GPVTREASKE MLDFLKHLET TDNIKVWFNN 1620
KGWHALVSFL NVAHNAILRA SLPRDRDPEE YGITVISQPL NLTKEQLSDI TVLTTSVDAV 1680
VAICVIFAMS FVPASFVLYL IQERVTKAKH LQFISGVSPT TYWLTNFLWD IMNYAVSAGL 1740
VVGIFIGFQK KAYTSPDNLP ALVSLLMLYG WAVIPMMYPA SFLFEVPSTA YVALSCANLF 1800
IGINSSAITF VLELFENNRT LLRFNAMLRK LLIVFPHFCL GRGLIDLALS QAVTDVYAQF 1860
GEEYSANPFQ WDLIGKNLVA MAIEGVVYFL LTLLIQHHFF LTRWIAEPAR EPVFDEDDDV 1920
AEERQRVMSG GNKTDILKLN ELTKVYSGSS SPAVDRLCVG VRPGECFGLL GVNGAGKTTT 1980
FKMLTGDTTV TSGDATVAGK SILTSISDVH QNMGYCPQFD AIDDLLTGRE HLYLYARLRG 2040
VPSKEIEKVA NWGIQSLGLS LYADRLAGTY SGGNKRKLST AIALTGCPPL LLLDEPTTGM 2100
DPQARRMLWN TIVSIIREGR AVVLTSHSME ECEALCTRLA IMVKGTFQCL GTIQHLKYKF 2160
GDGYIVTMKI KSPKDDLLPD LNPVEQFFQG NFPGSVQRER HHSMLQFQVP SSSLARIFQL 2220
LISHKDSLLI EEYSVTQTTL DQVFVNFAKQ QTETYDLPLH PRAAGASWQA KLEEKSGRLQ 2280
TQEPLPAGSE QLANGSNPTA AEDKHTRSPQ 2310 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; TAS:MGI. GO:0004012; F:phospholipid-translocating ATPase activity; IMP:MGI. GO:0006649; P:phospholipid transfer to membrane; IMP:MGI. GO:0045494; P:photoreceptor cell maintenance; IMP:MGI. GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
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PRINTS | |