UniProt Accession

 S23A2_HUMAN; Q9UGH3; Q8WWR4; Q92512; Q96D54; Q9UNU1; Q9UP85 

Genbank Protein ID

 AF058319; AJ269478; AF164142; AF092511; AJ292318; AY380556; D87075; AL389886; BC013112 

Genbank Nucleotide ID

 AAC78806.1; CAB58120.1; AAF80493.1; AAD11783.1; CAC83100.1; AAQ79775.1; BAA13244.2; CAC16126.1; AAH13112.1 

Protein Name

 Solute carrier family 23 member 2 

Protein Synonyms/Alias

 Na(+)/L-ascorbic acid transporter 2; Nucleobase transporter-like 1 protein; Sodium-dependent vitamin C transporter 2; hSVCT2; Yolk sac permease-like molecule 2 

Gene Name

 SLC23A2 

Gene Synonyms/Alias

 KIAA0238; NBTL1; SLC23A1; SVCT2; YSPL2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	IGKNTTSKSMEAGSS	ubiquitination	[1]
22	AGSSTEGKYEDEAKH	ubiquitination	[1]
184	RAILSLDKWKCNTTD	ubiquitination	[2]
298	KFPLPIYKSKKGWTA	ubiquitination	[1]
612	FGMNIIKKYRCFSYL	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. 

Sequence Annotation

 MOD_RES 78 78 Phosphoserine (By similarity).
 MOD_RES 79 79 Phosphothreonine (By similarity).
 MOD_RES 81 81 Phosphoserine.
 MOD_RES 649 649 Phosphothreonine (By similarity).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 650 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0009925; C:basal plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0008520; F:L-ascorbate:sodium symporter activity; IEA:Compara.
 GO:0015205; F:nucleobase transmembrane transporter activity; TAS:ProtInc.
 GO:0070890; F:sodium-dependent L-ascorbate transmembrane transporter activity; IDA:UniProtKB.
 GO:0008523; F:sodium-dependent multivitamin transmembrane transporter activity; NAS:UniProtKB.
 GO:0019852; P:L-ascorbic acid metabolic process; NAS:UniProtKB.
 GO:0015993; P:molecular hydrogen transport; NAS:UniProtKB.
 GO:0006139; P:nucleobase-containing compound metabolic process; TAS:ProtInc.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0070904; P:transepithelial L-ascorbic acid transport; IDA:UniProtKB. 

Interpro

 IPR006042; Xan_ur_permease.
 IPR006043; Xant/urac/vitC. 

Pfam

 PF00860; Xan_ur_permease 

SMART

  

PROSITE

 PS01116; XANTH_URACIL_PERMASE 

PRINTS