CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028959
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Spectrin alpha chain, non-erythrocytic 1 
Protein Synonyms/Alias
  
Gene Name
 Sptan1 
Gene Synonyms/Alias
 Spna2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
63LEKWIQEKLQVASDEubiquitination[1]
73VASDENYKDPTNLQGubiquitination[1]
441ASDEVREKLSILSEEubiquitination[1]
514KKHEDFEKSLSAQEEubiquitination[1]
633SRIDALEKAGQKLIDubiquitination[1]
718TNVQNLQKKHALLEAubiquitination[1]
803EETWIREKEPIAASTubiquitination[1]
814AASTNRGKDLIGVQNubiquitination[1]
824IGVQNLLKKHQALQAubiquitination[1]
909AESWMREKEPIVGSTubiquitination[1]
920VGSTDYGKDEDSAEAubiquitination[1]
969PMDDETGKELVLALYubiquitination[1]
981ALYDYQEKSPREVTMubiquitination[1]
990PREVTMKKGDILTLLubiquitination[1]
1022FVPAAYVKKLDPAQSubiquitination[1]
1057DNQTRITKEAGSVSLubiquitination[1]
1067GSVSLRMKQVEELYQubiquitination[1]
1082SLLELGEKRKGMLEKubiquitination[1]
1138KKFDDFQKDLKANESubiquitination[1]
1152SRLKDINKVAEDLESubiquitination[1]
1187PRDEADSKTASPWKSubiquitination[1]
1288DLAALGDKVNSLGETubiquitination[1]
1369VSSDELAKDVTGAEAubiquitination[1]
1419ASPEIKEKLDILDQEubiquitination[1]
1473AFLNTEDKGDSLDSVubiquitination[1]
1546QMIEKRSKLGESQTLubiquitination[1]
1580TASDESYKDPTNIQLubiquitination[1]
1635AGSEDAVKARLAALAubiquitination[1]
1651QWQFLVQKSAEKSQKubiquitination[1]
1720SAHEDRLKDLNSQADubiquitination[1]
1834GVLDTGKKLSDDNTIubiquitination[1]
2000VESWIGEKENSLKTDubiquitination[1]
2052KDQLLAAKHIQSKAIubiquitination[1]
2057AAKHIQSKAIEARHAubiquitination[1]
2093EAQSHFRKVEDLFLTubiquitination[1]
2132CNSLEEIKALREAHDubiquitination[1]
2409SRETENVKSSEEIESubiquitination[1]
2431EGKPYVTKEELYQNLubiquitination[1]
2451DYCVSHMKPYVDGKGubiquitination[1]
2457MKPYVDGKGRELPTAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2477 AA 
Protein Sequence
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ RDAEELEKWI 60
QEKLQVASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAIV KLDETGNLMI SEGHFASETI 120
RTRLMELHRQ WELLLEKMRE KGIKLLQAQK LVQYLRECED VMDWINDKEA IVTSEELGQD 180
LEHVEVLQKK FEEFQTDLAA HEERVNEVSQ FAAKLIQEQH PEEELIKTKQ DEVNAAWQRL 240
KGLALQRQGK LFGAAEVQRF NRDVDETIGW IKEKEQLMAS DDFGRDLASV QALLRKHEGL 300
ERDLAALEDK VKALCAEADR LQQSHPLSAS QIQVKREELI TNWEQIRTLA AERHARLDDS 360
YRLQRFLADF RDLTSWVTEM KALINADELA NDVAGAEALL DRHQEHKGEI DAHEDSFKSA 420
DESGQALLAA SHYASDEVRE KLSILSEERT ALLELWELRR QQYEQCMDLQ LFYRDTEQVD 480
NWMSKQEAFL LNEDLGDSLD SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA 540
MEDVATRRDA LLSRRNALHE RAMHRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA 600
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYAKEEVA ARMNEVISLW 660
KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH LASDDYGKDL TNVQNLQKKH 720
ALLEADVAAH QDRIDGITIQ ARQFQDAGHF DAENIKKKQE ALVARYEALK EPMVARKQKL 780
ADSLRLQQLF RDVEDEETWI REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI 840
KAVTQKGNAM VEEGHFAAED VKAKLSELNQ KWEALKAKAS QRRQDLEDSL QAQQYFADAN 900
EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR EQAQSCRQQV 960
APMDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST NKDWWKVEVN DRQGFVPAAY 1020
VKKLDPAQSA SRENLLEEQG SIALRQGQID NQTRITKEAG SVSLRMKQVE ELYQSLLELG 1080
EKRKGMLEKS CKKFMLFREA NELQQWITEK EAALTNEEVG ADLEQVEVLQ KKFDDFQKDL 1140
KANESRLKDI NKVAEDLESE GLMAEEVQAV QQQEVYGAMP RDEADSKTAS PWKSARLMVH 1200
TVATFNSIKE LNERWRSLQQ LAEERSQLLG SAHEVQRFHR DADETKEWIE EKNQALNTDN 1260
YGHDLASVQA LQRKHEGFER DLAALGDKVN SLGETAQRLI QSHPESAEDL KEKCTELNQA 1320
WTSLGKRADQ RKAKLGDSHD LQRFLSDFRD LMSWINGIRG LVSSDELAKD VTGAEALLER 1380
HQEHRTEIDA RAGTFQAFEQ FGQQLLAHGH YASPEIKEKL DILDQERTDL EKAWVQRRMM 1440
LDHCLELQLF HRDCEQAENW MAAREAFLNT EDKGDSLDSV EALIKKHEDF DKAINVQEEK 1500
IAALQAFADQ LIAVDHYAKG DIANRRNEVL DRWRRLKAQM IEKRSKLGES QTLQQFSRDV 1560
DEIEAWISEK LQTASDESYK DPTNIQLSKL LSKHQKHQAF EAELHANADR IRGVIDMGNS 1620
LIERGACAGS EDAVKARLAA LADQWQFLVQ KSAEKSQKLK EANKQQNFNT GIKDFDFWLS 1680
EVEALLASED YGKDLASVNN LLKKHQLLEA DISAHEDRLK DLNSQADSLM TSSAFDTSQV 1740
KEKRDTINGR FQKIKSMATS RRAKLSESHR LHQFFRDMDD EESWIKEKKL LVSSEDYGRD 1800
LTGVQNLRKK HKRLEAELAA HEPAIQGVLD TGKKLSDDNT IGQEEIQQRL AQFVEHWKEL 1860
KQLAAARGQR LEESLEYQQF VANVEEEEAW INEKMTLVAS EDYGDTLAAI QGLLKKHEAF 1920
ETDFTVHKDR VNDVCTNGQD LIKKNNHHEE NISSKMKGLN GKVSDLEKAA AQRKAKLDEN 1980
SAFLQFNWKA DVVESWIGEK ENSLKTDDYG RDLSSVQTLL TKQETFDAGL QAFQQEGIAN 2040
ITALKDQLLA AKHIQSKAIE ARHASLMKRW TQLLANSATR KKKLLEAQSH FRKVEDLFLT 2100
FAKKASAFNS WFENAEEDLT DPVRCNSLEE IKALREAHDA FRSSLSSAQA DFNQLAELDR 2160
QIKSFRVASN PYTWFTMEAL EETWRNLQKI IKERELELQK EQRRQEENDK LRQEFAQHAN 2220
AFHQWIQETR TYLLDGSCMV EESGTLESQL EATKRKHQEI RAMRSQLKKI EDLGAAMEEA 2280
LILDNKYTEH STVGLAQQWD QLDQLGMRMQ HNLEQQIQAR NTTGVTEEAL KEFSMMFKHF 2340
DKDKSGRLNH QEFKSCLRSL GYDLPMVEEG EPDPEFEAIL DTVDPNRDGH VSLQEYMAFM 2400
ISRETENVKS SEEIESAFRA LSSEGKPYVT KEELYQNLTR EQADYCVSHM KPYVDGKGRE 2460
LPTAFDYVEF TRSLFVN 2477 
Gene Ontology
 GO:0032437; C:cuticular plate; IDA:MGI.
 GO:0005916; C:fascia adherens; IDA:MGI.
 GO:0016328; C:lateral plasma membrane; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0046982; F:protein heterodimerization activity; IDA:MGI.
 GO:0030507; F:spectrin binding; IDA:MGI. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR014837; EF-hand_Ca_insen.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001452; SH3_domain.
 IPR018159; Spectrin/alpha-actinin.
 IPR013315; Spectrin_alpha_SH3.
 IPR002017; Spectrin_repeat. 
Pfam
 PF13499; EF_hand_5
 PF08726; efhand_Ca_insen
 PF00018; SH3_1
 PF00435; Spectrin 
SMART
 SM00054; EFh
 SM00326; SH3
 SM00150; SPEC 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50002; SH3 
PRINTS
 PR00452; SH3DOMAIN.
 PR01887; SPECTRNALPHA.