UniProt Accession

 BINCA_HUMAN; Q96LW7; Q5BJH8; Q9BSY2 

Genbank Protein ID

 AK057716; AL451065; BC004500; BC038856 

Genbank Nucleotide ID

 BAB71550.1; CAI95110.1; AAH04500.1; AAH38856.1 

Protein Name

 Bcl10-interacting CARD protein 

Protein Synonyms/Alias

 BinCARD 

Gene Name

 C9orf89 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
46	YPQILTNKEAEKFRN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. 

Sequence Annotation

 DOMAIN 8 99 CARD.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; NAS:UniProtKB.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0050700; F:CARD domain binding; NAS:UniProtKB.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; NAS:UniProtKB. 

Interpro

  

Pfam

  

SMART

  

PROSITE

 PS50209; CARD 

PRINTS