UniProt Accession

 EF1D_HUMAN; P29692; B4DDU4; D3DWK3; E9PBQ9; Q4VBZ6; Q969J1; Q96I38 

Genbank Protein ID

 Z21507; BT007242; AK293339; AC067930; CH471162; CH471162; CH471162; CH471162; CH471162; BC007847; BC009907; BC012819; BC062535; BC094806 

Genbank Nucleotide ID

 CAA79716.1; AAP35906.1; BAG56855.1; EAW82227.1; EAW82228.1; EAW82229.1; EAW82230.1; EAW82232.1; AAH07847.1; AAH09907.1; AAH12819.1; AAH62535.1; AAH94806.1 

Protein Name

 Elongation factor 1-delta 

Protein Synonyms/Alias

 EF-1-delta; Antigen NY-CO-4 

Gene Name

 EEF1D 

Gene Synonyms/Alias

 EF1D 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	TNFLAHEKIWFDKFK	ubiquitination	[1]
15	HEKIWFDKFKYDDAE	ubiquitination	[1]
17	KIWFDKFKYDDAERR	acetylation	[2]
59	RARENIQKSLAGSSG	ubiquitination	[1, 3]
107	ELQQAISKLEARLNV	acetylation	[2]
107	ELQQAISKLEARLNV	ubiquitination	[1, 3, 4]
117	ARLNVLEKSSPGHRA	acetylation	[2]
117	ARLNVLEKSSPGHRA	ubiquitination	[3]
189	YAEKKAKKPALVAKS	ubiquitination	[3]
232	GLVWGASKLVPVGYG	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. 

Sequence Annotation

 REGION 80 115 Leucine-zipper.
 REGION 173 281 Catalytic (GEF).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 17 17 N6-acetyllysine.
 MOD_RES 107 107 N6-acetyllysine.
 MOD_RES 117 117 N6-acetyllysine.
 MOD_RES 129 129 Phosphothreonine (By similarity).
 MOD_RES 133 133 Phosphoserine.
 MOD_RES 147 147 Phosphothreonine.
 MOD_RES 162 162 Phosphoserine; by CK2.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Elongation factor; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005853; C:eukaryotic translation elongation factor 1 complex; TAS:ProtInc.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0008135; F:translation factor activity, nucleic acid binding; TAS:ProtInc.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006414; P:translational elongation; TAS:Reactome. 

Interpro

 IPR018940; EF-1_beta_acid_region_euk.
 IPR014717; Transl_elong_EF1B/ribosomal_S6.
 IPR001326; Transl_elong_EF1B_B/D_CS.
 IPR014038; Transl_elong_fac_EF1B_bsu/dsu. 

Pfam

 PF10587; EF-1_beta_acid
 PF00736; EF1_GNE 

SMART

 SM00888; EF1_GNE 

PROSITE

 PS00824; EF1BD_1
 PS00825; EF1BD_2 

PRINTS